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Normal serum aminotransferase concentration and risk of mortality from liver diseases: Prospective cohort study

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dc.contributor.author김현창-
dc.contributor.author남정모-
dc.contributor.author서일-
dc.contributor.author지선하-
dc.date.accessioned2015-07-14T17:23:46Z-
dc.date.available2015-07-14T17:23:46Z-
dc.date.issued2004-
dc.identifier.issn0959-8138-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/112796-
dc.description.abstractOBJECTIVE: To examine the relation between the normal range of serum aminotransferase concentration and mortality from liver disease. DESIGN: Prospective cohort study. SETTING: Korea Medical Insurance Corporation study with eight years' follow up. PARTICIPANTS: 94,533 men and 47,522 women aged 35-59 years. MAIN OUTCOME MEASURE: Mortality from liver diseases according to death certificate. RESULTS: There was a positive association between the aminotransferase concentration, even within normal range (35-40 IU/l), and mortality from liver disease. Compared with the concentration < 20 IU/l, the adjusted relative risks for an aspartate aminotransferase concentration of 20-29 IU/l and 30-39 IU/l were 2.5 (95% confidence interval 2.0 to 3.0) and 8.0 (6.6 to 9.8) in men and 3.3 (1.7 to 6.4) and 18.2 (8.1 to 40.4) in women, respectively, The corresponding risks for alanine aminotransferase were 2.9 (2.4 to 3.5) and 9.5 (7.9 to 11.5) in men and 3.8 (1.9 to 7.7) and 6.6 (1.5 to 25.6) in women, respectively. According to receiver operating characteristic curves the best cut-off values for the prediction of liver disease in men were 31 IU/l for aspartate aminotransferase and 30 IU/l for alanine aminotransferase. CONCLUSION: People with slightly increased aminotransferase activity, but still within the normal range, should be closely observed and further investigated for liver diseases.-
dc.description.statementOfResponsibilityopen-
dc.format.extent983~986-
dc.relation.isPartOfBMJ-BRITISH MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHEpidemiologic Methods-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHKorea/epidemiology-
dc.subject.MESHLiver Diseases/enzymology*-
dc.subject.MESHLiver Diseases/mortality-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrognosis-
dc.subject.MESHSex Distribution-
dc.subject.MESHTransaminases/blood*-
dc.titleNormal serum aminotransferase concentration and risk of mortality from liver diseases: Prospective cohort study-
dc.typeArticle-
dc.contributor.collegeGraduate School of Public Health (보건대학원)-
dc.contributor.departmentGraduate School of Public Health (보건대학원)-
dc.contributor.googleauthorHyeon Chang Kim-
dc.contributor.googleauthorChung Mo Nam-
dc.contributor.googleauthorIl Suh-
dc.contributor.googleauthorDae Kyu Oh-
dc.contributor.googleauthorKwang Hyub Han-
dc.contributor.googleauthorSun Ha Jee-
dc.identifier.doi10.1136/bmj.38050.593634.63-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01142-
dc.contributor.localIdA01264-
dc.contributor.localIdA01899-
dc.contributor.localIdA03965-
dc.relation.journalcodeJ00419-
dc.identifier.eissn1756-1833-
dc.identifier.pmid15028636-
dc.contributor.alternativeNameKim, Hyeon Chang-
dc.contributor.alternativeNameNam, Jung Mo-
dc.contributor.alternativeNameSuh, Il-
dc.contributor.alternativeNameJee, Sun Ha-
dc.contributor.affiliatedAuthorKim, Hyeon Chang-
dc.contributor.affiliatedAuthorNam, Jung Mo-
dc.contributor.affiliatedAuthorSuh, Il-
dc.contributor.affiliatedAuthorJee, Sun Ha-
dc.rights.accessRightsfree-
dc.citation.volume328-
dc.citation.number7446-
dc.citation.startPage983-
dc.citation.endPage986-
dc.identifier.bibliographicCitationBMJ-BRITISH MEDICAL JOURNAL, Vol.328(7446) : 983-986, 2004-
dc.identifier.rimsid44512-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers

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