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Rhabdoid Cholangiocarcinoma: A Variant of Cholangiocarcinoma with Aggressive Behavior

 Beom Jin Lim  ;  Kyung Sik Kim  ;  Young Nyun Park  ;  Chanil Park  ;  Myeong Jin Kim  ;  Joon Seok Lim 
 YONSEI MEDICAL JOURNAL, Vol.45(3) : 543-546, 2004 
Journal Title
Issue Date
Adult ; Cholangiocarcinoma/chemistry ; Cholangiocarcinoma/pathology* ; Female ; Humans ; Liver Neoplasms/chemistry ; Liver Neoplasms/pathology* ; Magnetic Resonance Imaging ; Prognosis ; Rhabdoid Tumor/chemistry ; Rhabdoid Tumor/pathology* ; Tomography, X-Ray Computed ; Vimentin/analysis
Cholangiocarcinoma ; rhabdoid tumor ; carcinosarcoma ; vimentin
A rhabdoid cholangiocarcinoma is a very rare variant of sarcomatous cholangiocarcinomas. Here, we report a vimentin positive cholangiocarcinoma showing rhabdoid features in the entire tumor, with a very aggressive behavior. A 41-year-old woman was admitted to our hospital due to a huge hepatic mass. The resected liver revealed a 17×15 cm sized solid mass with extensive necrosis and an infiltrative border. On microscopic examination, the entire tumor was composed of loosely cohesive round to polygonal cells, with rhabdoid features having abundant eosinophilic glassy cytoplasm and eccentrically located vesicular nuclei. Some tumor cells contained intracytoplasmic mucin vacuoles, but definite areas of glandular differentiation or spindle cell were not found. Immunohistochemical staining showed a diffuse strong positive reaction to pan-cytokeratin and vimentin, and focal positivity for the carcinoembryonic antigen. Other immunohistochemical stainings for cytokeratin 7, cytokeratin 20, S-100 protein, HMB-45, desmin, alpha-smooth muscle actin, c-kit, CD34, alpha-fetoprotein, anti-hepatocyte antigen, chromogranin and synaptophysin were all negative. After two months, the patient developed a local recurrence along the resection margin, and multiple hematogenous metastases to the lung and liver were seen on the follow-up CT scan.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Sik(김경식) ORCID logo https://orcid.org/0000-0001-9498-284X
Kim, Myeong Jin(김명진) ORCID logo https://orcid.org/0000-0001-7949-5402
Park, Young Nyun(박영년) ORCID logo https://orcid.org/0000-0003-0357-7967
Park, Chan Il(박찬일)
Lim, Beom Jin(임범진) ORCID logo https://orcid.org/0000-0003-2856-0133
Lim, Joon Seok(임준석) ORCID logo https://orcid.org/0000-0002-0334-5042
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