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Retinoic Acid Receptor-β Expression in Stage I Non-Small Cell Lung Cancer and Adjacent Normal Appearing Bronchial Epithelium

 Yoon Soo Chang  ;  Jae Ho Chung  ;  Se Kyu Kim  ;  Sung Kyu Kim  ;  Joon Chang  ;  Young Sam Kim  ;  Kyung Young Chung  ;  Dong Hwan Shin 
 YONSEI MEDICAL JOURNAL, Vol.45(3) : 435-442, 2004 
Journal Title
Issue Date
Adult ; Aged ; Biomarkers, Tumor/metabolism* ; Bronchi/metabolism ; Bronchi/pathology ; Carcinoma, Non-Small-Cell Lung/metabolism* ; Carcinoma, Non-Small-Cell Lung/pathology ; Down-Regulation ; Female ; Humans ; Immunohistochemistry ; Lung Neoplasms/metabolism* ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Neoplasm Staging ; Receptors, Retinoic Acid/metabolism* ; Respiratory Mucosa/pathology*
Biomarker ; chemoprevention ; retinoic acids ; retinoic acid receptor-β ; non-small cell lung cancer
Retinoic acid receptor-(RAR-β) is induced by and mediates the growth-inhibitory and apoptotic effects of retinoic acid (RA), suggesting that loss of RAR-βexpression may be one of the critical events involved in the carcinogenesis/progression of non-small cell lung cancer (NSCLC) and in the responsiveness to retinoid chemotherapy. However, recent contradictory reports that the expression of RAR-β is associated with poor clinical outcome, and the fact that treatment of serum-deprived type 2 alveolar cells with RA leads to a stimulation of cell proliferation, require the verification of RAR-β as a biomarker of chemoprevention or prognosis. The expression status of RAR-β in cancer cells and adjacent normal appearing bronchial epithelium from 39 patients, diagnosed as stage I NSCLC and undergone a curative lung resection, was analyzed in paraffin-embedded tissue sections by IHC staining. The normal appearing bronchial epithelium of 14 out of 33 (42.4%) specimens expressed RAR-β, whereas 22 out of the 39 (56.4%) stage I NSCLC specimens expressed RAR-β. RAR-β was more frequently expressed in the adenocarcinoma (72.7%) than in the squamous cell carcinoma (31.3%) (p=0.026). Neither the expression status in normal appearing adjacent tissue nor that in the tumor tissue had prognostic implications. The higher expression of RAR-β in cancer tissue, the focal and uneven distribution in normal appearing adjacent bronchial epithelium, and inconsistency with the corresponding tumor tissue, suggest that the expression status of RAR-β as a biomarker for chemoprevention/early diagnosis or the prognosis of NSCLC requires further consideration.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sung Kyu(김성규)
Kim, Se Kyu(김세규)
Kim, Young Sam(김영삼) ORCID logo https://orcid.org/0000-0001-9656-8482
Shin, Dong Hwan(신동환)
Chang, Yoon Soo(장윤수) ORCID logo https://orcid.org/0000-0003-3340-4223
Chang, Joon(장준) ORCID logo https://orcid.org/0000-0003-4542-6841
Chung, Kyung Young(정경영)
Cheong, Jae Ho(정재호) ORCID logo https://orcid.org/0000-0002-1703-1781
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