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Retinoic Acid Receptor-β Expression in Stage I Non-Small Cell Lung Cancer and Adjacent Normal Appearing Bronchial Epithelium

DC Field Value Language
dc.contributor.author정경영-
dc.contributor.author정재호-
dc.contributor.author김성규-
dc.contributor.author김세규-
dc.contributor.author김영삼-
dc.contributor.author신동환-
dc.contributor.author장윤수-
dc.contributor.author장준-
dc.date.accessioned2015-07-14T17:16:03Z-
dc.date.available2015-07-14T17:16:03Z-
dc.date.issued2004-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/112541-
dc.description.abstractRetinoic acid receptor-(RAR-β) is induced by and mediates the growth-inhibitory and apoptotic effects of retinoic acid (RA), suggesting that loss of RAR-βexpression may be one of the critical events involved in the carcinogenesis/progression of non-small cell lung cancer (NSCLC) and in the responsiveness to retinoid chemotherapy. However, recent contradictory reports that the expression of RAR-β is associated with poor clinical outcome, and the fact that treatment of serum-deprived type 2 alveolar cells with RA leads to a stimulation of cell proliferation, require the verification of RAR-β as a biomarker of chemoprevention or prognosis. The expression status of RAR-β in cancer cells and adjacent normal appearing bronchial epithelium from 39 patients, diagnosed as stage I NSCLC and undergone a curative lung resection, was analyzed in paraffin-embedded tissue sections by IHC staining. The normal appearing bronchial epithelium of 14 out of 33 (42.4%) specimens expressed RAR-β, whereas 22 out of the 39 (56.4%) stage I NSCLC specimens expressed RAR-β. RAR-β was more frequently expressed in the adenocarcinoma (72.7%) than in the squamous cell carcinoma (31.3%) (p=0.026). Neither the expression status in normal appearing adjacent tissue nor that in the tumor tissue had prognostic implications. The higher expression of RAR-β in cancer tissue, the focal and uneven distribution in normal appearing adjacent bronchial epithelium, and inconsistency with the corresponding tumor tissue, suggest that the expression status of RAR-β as a biomarker for chemoprevention/early diagnosis or the prognosis of NSCLC requires further consideration.-
dc.description.statementOfResponsibilityopen-
dc.format.extent435~442-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBiomarkers, Tumor/metabolism*-
dc.subject.MESHBronchi/metabolism-
dc.subject.MESHBronchi/pathology-
dc.subject.MESHCarcinoma, Non-Small-Cell Lung/metabolism*-
dc.subject.MESHCarcinoma, Non-Small-Cell Lung/pathology-
dc.subject.MESHDown-Regulation-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHLung Neoplasms/metabolism*-
dc.subject.MESHLung Neoplasms/pathology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHReceptors, Retinoic Acid/metabolism*-
dc.subject.MESHRespiratory Mucosa/pathology*-
dc.titleRetinoic Acid Receptor-β Expression in Stage I Non-Small Cell Lung Cancer and Adjacent Normal Appearing Bronchial Epithelium-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorYoon Soo Chang-
dc.contributor.googleauthorJae Ho Chung-
dc.contributor.googleauthorSe Kyu Kim-
dc.contributor.googleauthorSung Kyu Kim-
dc.contributor.googleauthorJoon Chang-
dc.contributor.googleauthorYoung Sam Kim-
dc.contributor.googleauthorKyung Young Chung-
dc.contributor.googleauthorDong Hwan Shin-
dc.identifier.doi10.3349/ymj.2004.45.3.435-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid15227730-
dc.subject.keywordBiomarker-
dc.subject.keywordchemoprevention-
dc.subject.keywordretinoic acids-
dc.subject.keywordretinoic acid receptor-β-
dc.subject.keywordnon-small cell lung cancer-
dc.contributor.alternativeNameChung, Kyung Young-
dc.contributor.alternativeNameCheong, Jae Ho-
dc.contributor.alternativeNameKim, Sung Kyu-
dc.contributor.alternativeNameKim, Se Kyu-
dc.contributor.alternativeNameKim, Young Sam-
dc.contributor.alternativeNameShin, Dong Hwan-
dc.contributor.alternativeNameChang, Yoon Soo-
dc.contributor.alternativeNameChang, Joon-
dc.rights.accessRightsfree-
dc.citation.volume45-
dc.citation.number3-
dc.citation.startPage435-
dc.citation.endPage442-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.45(3) : 435-442, 2004-
dc.identifier.rimsid57735-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

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