225 169

Cited 23 times in

Hepatitis B virus X protein modulates peroxisome proliferator-activated receptor γ through protein–protein interaction

Authors
 Youn-Hee Choi  ;  Ha-il Kim  ;  Jeon Han Park  ;  Se Jong Kim  ;  Yong-ho Ahn  ;  Jae Myun Lee  ;  Mi-Ock Lee  ;  Hyeseong Cho  ;  Dae-Yeul Yu  ;  Je Kyung Seong 
Citation
 FEBS Letters, Vol.557(1-3) : 73-80, 2004 
Journal Title
 FEBS Letters 
ISSN
 0014-5793 
Issue Date
2004
Abstract
Ligand activation of peroxisome proliferator-activated receptor γ (PPARγ) has been reported to induce growth inhibition and apoptosis in various cancers including hepatocellular carcinoma (HCC). However, the effect of hepatitis B virus X protein (HBx) on PPARγ activation has not been characterized in hepatitis B virus (HBV)-associated HCC. Herein, we demonstrated that HBx counteracted growth inhibition caused by PPARγ ligand in HBx-associated HCC cells. We found that HBx bound to DNA binding domain of PPARγ and HBx/PPARγ interaction blocked nuclear localization and binding to recognition site of PPARγ. HBx significantly suppressed a PPARγ-mediated transactivation. These results suggest that HBx modulates PPARγ function through protein–protein interaction.
Files in This Item:
T200401032.pdf Download
DOI
10.1016/S0014-5793(03)01449-2
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
김하일(Kim, Ha Il)
박전한(Park, Jeon Han) ORCID logo https://orcid.org/0000-0001-9604-3205
이미옥(Lee, Mi Ock)
이재면(Lee, Jae Myun) ORCID logo https://orcid.org/0000-0002-5273-3113
최윤희(Choi, Youn Hee)
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/112493
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse