Cited 27 times in
Hepatitis B virus X protein modulates peroxisome proliferator-activated receptor γ through protein–protein interaction
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김하일 | - |
dc.contributor.author | 박전한 | - |
dc.contributor.author | 이미옥 | - |
dc.contributor.author | 이재면 | - |
dc.contributor.author | 최윤희 | - |
dc.date.accessioned | 2015-07-14T17:14:39Z | - |
dc.date.available | 2015-07-14T17:14:39Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/112493 | - |
dc.description.abstract | Ligand activation of peroxisome proliferator-activated receptor γ (PPARγ) has been reported to induce growth inhibition and apoptosis in various cancers including hepatocellular carcinoma (HCC). However, the effect of hepatitis B virus X protein (HBx) on PPARγ activation has not been characterized in hepatitis B virus (HBV)-associated HCC. Herein, we demonstrated that HBx counteracted growth inhibition caused by PPARγ ligand in HBx-associated HCC cells. We found that HBx bound to DNA binding domain of PPARγ and HBx/PPARγ interaction blocked nuclear localization and binding to recognition site of PPARγ. HBx significantly suppressed a PPARγ-mediated transactivation. These results suggest that HBx modulates PPARγ function through protein–protein interaction. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 73~80 | - |
dc.relation.isPartOf | FEBS LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenoviridae | - |
dc.subject.MESH | Apoptosis/drug effects | - |
dc.subject.MESH | Base Sequence | - |
dc.subject.MESH | Carcinoma, Hepatocellular/pathology | - |
dc.subject.MESH | Carcinoma, Hepatocellular/virology | - |
dc.subject.MESH | Cell Division/drug effects | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | DNA Primers | - |
dc.subject.MESH | Genes, Reporter | - |
dc.subject.MESH | Genetic Vectors | - |
dc.subject.MESH | Green Fluorescent Proteins | - |
dc.subject.MESH | Hepatitis B Antigens/chemistry | - |
dc.subject.MESH | Hepatitis B Antigens/pharmacology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Ligands | - |
dc.subject.MESH | Liver Neoplasms/pathology | - |
dc.subject.MESH | Liver Neoplasms/virology | - |
dc.subject.MESH | Luminescent Proteins/genetics | - |
dc.subject.MESH | Protein Transport/drug effects | - |
dc.subject.MESH | Receptors, Cytoplasmic and Nuclear/chemistry | - |
dc.subject.MESH | Receptors, Cytoplasmic and Nuclear/drug effects | - |
dc.subject.MESH | Receptors, Cytoplasmic and Nuclear/genetics | - |
dc.subject.MESH | Receptors, Cytoplasmic and Nuclear/metabolism* | - |
dc.subject.MESH | Recombinant Fusion Proteins/chemistry | - |
dc.subject.MESH | Recombinant Fusion Proteins/drug effects | - |
dc.subject.MESH | Recombinant Fusion Proteins/metabolism | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Trans-Activators/chemistry | - |
dc.subject.MESH | Trans-Activators/metabolism | - |
dc.subject.MESH | Trans-Activators/pharmacology* | - |
dc.subject.MESH | Transcription Factors/chemistry | - |
dc.subject.MESH | Transcription Factors/drug effects | - |
dc.subject.MESH | Transcription Factors/genetics | - |
dc.subject.MESH | Transcription Factors/metabolism* | - |
dc.subject.MESH | Transfection | - |
dc.subject.MESH | Tumor Cells, Cultured | - |
dc.title | Hepatitis B virus X protein modulates peroxisome proliferator-activated receptor γ through protein–protein interaction | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | Youn-Hee Choi | - |
dc.contributor.googleauthor | Ha-il Kim | - |
dc.contributor.googleauthor | Jeon Han Park | - |
dc.contributor.googleauthor | Se Jong Kim | - |
dc.contributor.googleauthor | Yong-ho Ahn | - |
dc.contributor.googleauthor | Jae Myun Lee | - |
dc.contributor.googleauthor | Mi-Ock Lee | - |
dc.contributor.googleauthor | Hyeseong Cho | - |
dc.contributor.googleauthor | Dae-Yeul Yu | - |
dc.contributor.googleauthor | Je Kyung Seong | - |
dc.identifier.doi | 10.1016/S0014-5793(03)01449-2 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J00890 | - |
dc.identifier.eissn | 1873-3468 | - |
dc.identifier.pmid | 14741344 | - |
dc.subject.keyword | Hepatitis B virus X protein | - |
dc.subject.keyword | Peroxisome proliferator-activated receptor γ | - |
dc.subject.keyword | Transactivation | - |
dc.subject.keyword | Protein–protein interaction | - |
dc.subject.keyword | PPARγ, peroxisome proliferator-activated receptor γ | - |
dc.subject.keyword | HCC, hepatocellular carcinoma | - |
dc.subject.keyword | HBx, hepatitis B virus X protein | - |
dc.subject.keyword | HBV, hepatitis B virus | - |
dc.subject.keyword | RXR, retinoid X receptor | - |
dc.subject.keyword | PPRE, peroxisome proliferator response element | - |
dc.subject.keyword | HBx-TG, hepatitis B virus X protein transgenic | - |
dc.subject.keyword | EMSA, electrophoretic mobility shift assay | - |
dc.subject.keyword | HA, hemagglutinin | - |
dc.subject.keyword | NE, nuclear extract | - |
dc.subject.keyword | DBD, DNA binding domain | - |
dc.subject.keyword | LBD, ligand binding domain | - |
dc.subject.keyword | NLS, nuclear localization signal | - |
dc.subject.keyword | IFA, immunofluorescence assay | - |
dc.subject.keyword | rHBx, recombinant hepatitis B virus X protein | - |
dc.contributor.alternativeName | Kim, Ha Il | - |
dc.contributor.alternativeName | Park, Jeon Han | - |
dc.contributor.alternativeName | Lee, Mi Ock | - |
dc.contributor.alternativeName | Lee, Jae Myun | - |
dc.contributor.alternativeName | Choi, Youn Hee | - |
dc.contributor.affiliatedAuthor | 최윤희 | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 557 | - |
dc.citation.number | 1-3 | - |
dc.citation.startPage | 73 | - |
dc.citation.endPage | 80 | - |
dc.identifier.bibliographicCitation | FEBS LETTERS, Vol.557(1-3) : 73-80, 2004 | - |
dc.identifier.rimsid | 56213 | - |
dc.type.rims | ART | - |
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