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자궁내막증에서 cyclins-CDKs와 CDKIs에 의한 세포주기 조절경로에 관한 연구

Other Titles
 Cell Cycle Signaling Pathway by Cyclins-CDKs and CDKIs in Endometriosis 
Authors
 정경아  ;  박기현  ;  송찬호  ;  조동제  ;  김세광  ;  서경  ;  이병석  ;  김영태  ;  배상욱  ;  손우현  ;  윤정미  ;  윤현숙 
Citation
 Korean Journal of Obstetrics and Gynecology (대한산부인과학회잡지), Vol.47(2) : 307-312, 2004 
Journal Title
Korean Journal of Obstetrics and Gynecology(대한산부인과학회잡지)
ISSN
 1738-5628 
Issue Date
2004
Keywords
Endometriosis ; Cyclin ; Cyclin dependent kinase ; Cyclin dependent kinase inhibitor ; Cell cycle signaling pathway
Abstract
Objective : To determine whether oxidants are formed as part of the cisplatin-induced apoptotic process, intracellular markers of oxidative stress were examined. Methods : Apoptotic death of HeLa cells by cisplatin was confirmed by flow cytometry. Results : The pre-treatment with glutathione (GSH) significantly attenuated cisplatin-induced apoptosis through the reduction of reactive oxygen species (ROS) accumulation and diminished caspases-3 and 9 protease activity. Furthermore, z-VAD-fink, an inhibitor of pan-caspase, effectively inhibited the activation of caspases and prevented apoptosis by cisplatin, although cisplatin-induced ROS generation was not attenuated. Conclusion : These data indicate that ROS may play a role as an upstream mediator of caspases. Taken together, our results suggest that oxidative stress mediates cisplatin-induced apoptosis in HeLa cells.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Sei Kwang(김세광)
Kim, Young Tae(김영태) ORCID logo https://orcid.org/0000-0002-7347-1052
Park, Ki Hyun(박기현)
Bai, Sang Wook(배상욱) ORCID logo https://orcid.org/0000-0001-7724-7552
Seo, Kyung(서경)
Song, Chan Ho(송찬호)
Yoon, Hyun Sook(윤현숙)
Lee, Byung Seok(이병석) ORCID logo https://orcid.org/0000-0001-6001-2079
Cho, Dong Je(조동제)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/112223
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