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악성 종양과 동반된 신증후군의 임상 양상

Other Titles
 Clinical Characteristics of Nephrotic Syndrome Associated with Malignancy 
Authors
 박정탁  ;  김주성  ;  강신욱  ;  한대석  ;  이호영  ;  최규헌  ;  정현주  ;  이승철  ;  장태익  ;  이정은  ;  최훈영  ;  유태현  ;  류동열  ;  김형종 
Citation
 Korean Journal of Nephrology (대한신장학회지), Vol.23(5) : 738-745, 2004 
Journal Title
 Korean Journal of Nephrology (대한신장학회지) 
ISSN
 1225-0015 
Issue Date
2004
Keywords
Malignancy ; Nephrotic syndrome ; Renal biopsy
Abstract
Background: Even though there have been many case reports on nephrotic syndrome in patients with malignancy, an overall study on malignancy-associated nephrotic syndrome is rare in Korea. The purpose of this study was to explore the clinical and pathologic findings and clinical course of malignancy-associated nephrotic syndrome. Methods: From January, 1986 to December, 2003, the medical records of patients with nephrotic syndrome and concomitant malignancy were retrospectively reviewed. Results: Forty-eight patients (2.3%) out of 2,085 patients with nephrotic syndrome had concomitant malignant disease during the study period. The mean age of patients was 57.9±1.6 years with sex ratio of 2.4:1. The most common primary origin of malignancy was liver (8 patients, 16.7%) and lungs (8 patients, 16.7%), and adenocarcinoma (17 patients, 35.4 %) was the leading histologic type of malignancy. There was no significant difference in 24-hour urinary protein excretion among patients grouped by TNM stage. Percutaneous renal biopsy was performed in 26 patients (54.2%), renal pathology revealed membranous nephropathy and minimal change disease in 9 patients (34.6%) each, membranoproliferative glomerulonephritis in 6 (23.1%), and IgA nephropathy in 2 patients (7.7%). When the patients were divided into progression and remission group based on the clinical course of underlying malignancy, there were significantly more patients with improved nephrotic syndrome in the remission group than the progression group (55.0% vs. 0%, p<0.05). Conclusion: Malignancy should be considered as a cause of nephrotic syndrome in adults, and the treatment of underlying malignancy may affect the outcome of nephrotic syndrome in patients with malignancy.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Kim, Joo Sung(김주성)
Kim, Hyung Jong(김형종)
Ryu, Dong Ryeol(류동열)
Yoo, Tae Hyun(유태현) ORCID logo https://orcid.org/0000-0002-9183-4507
Lee, Jung Eun(이정은) ORCID logo https://orcid.org/0000-0003-0917-2872
Lee, Ho Yung(이호영)
Jeong, Hyeon Joo(정현주) ORCID logo https://orcid.org/0000-0002-9695-1227
Choi, Kyu Hun(최규헌) ORCID logo https://orcid.org/0000-0003-0095-9011
Choi, Hoon Young(최훈영) ORCID logo https://orcid.org/0000-0002-4245-0339
Han, Dae Suk(한대석)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/112107
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