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신체지표 및 비만도의 결정 요인으로서 IGFBP-3 Promoter Polymorphism

Other Titles
 Relations Between IGFBP-3 Promoter Polymorphism and Body Composition Parameters and Obesity 
Authors
 박종숙  ;  장윤수  ;  이현철  ;  김경래  ;  임승길  ;  차봉수  ;  안철우  ;  박진아  ;  조민호  ;  김똘미  ;  김철식  ;  남주영  ;  유경남 
Citation
 Journal of Korean Society for the Study of Obesity (대한비만학회지), Vol.13(3) : 187-194, 2004 
Journal Title
 Journal of Korean Society for the Study of Obesity (대한비만학회지) 
ISSN
 1226-4407 
Issue Date
2004
Keywords
IGFs ; IGFBP-3 ; IGFBP-3 promoter -202 locus A/C polymorphism
Abstract
Background: Insulin-like growth factor (IGF) binding protein-3 (IGFBP-3), which binds to the IGFs in the circulation and acts as a main reservoir of them, regulates their biologic activities either in a IGF receptor dependent or independent manner. Circulating levels of IGF-1 and IGFBP-3 vary considerably among individuals and have been implicated in various medical conditions. Methods: Single nucleotide polymorphism at the -202 locus of the IGFBP-3 promoter, which influences transcriptional activities and is related with circulating IGFBP-3 levels, was genotyped for 262 samples from a study population who is older than 40 years. Results: The frequency of each polymorphic variation at the -202 locus in these study population was AA =115 (43.9%), AC=125 (47.7%), and CC=22 (8.4%). In both genders, the subjects with the CC genotype were taller, whereas those with AC genotype had higher weight, BMI and BSA comparing those with the other genotypes, but these facts did not reach statistical significance. The prevalence of type 2 DM and the mean fasting blood glucose level did not differ among genotypes in the female gender. In the male population, however, the prevalence of type 2 DM was higher in the subjects with the AC genotype (p=0.016, chi-square-test), which is reflected by the elevated mean fasting glucose level (p=0.106, One-way ANOVA). Conclusion: IGFBP-3 promoter -202 locus A/C polymorphism, which reflects its serum level and further implicates IGFs bioactivity, was associated with a higher prevalence of type 2 DM in the male gender. Although it did not reach statistical significance, the subjects with the CC genotype were the tallest among the genotypes and the subjects with the AC genotype had the highest BMI and weight, suggesting that IGFBP-3 might well play a role in body composition.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Rae(김경래)
Kim, Dol Mi(김똘미)
Kim, Chul Sik(김철식)
Nam, Ju Young(남주영)
Park, Jong Suk(박종숙) ORCID logo https://orcid.org/0000-0002-5385-1373
Park, Jina(박진아)
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Yoo, Kyeong Nam(유경남)
Lee, Hyun Chul(이현철)
Lim, Sung Kil(임승길)
Chang, Yoon Soo(장윤수) ORCID logo https://orcid.org/0000-0003-3340-4223
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/112091
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