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백서각막에 엑시머레이저 조사 후 각막상피 재생시 양막에 의한 laminin의 발현

Other Titles
 Expression of Laminin with Amniotic Membrane Transplantation in Corneal Epithelial Wound Healing folloeing Excimer Laser Keratectomy in Rats 
Authors
 이용주  ;  이형근  ;  성공제  ;  서경률  ;  김응권 
Citation
 JOURNAL OF THE KOREAN OPHTHALMOLOGICAL SOCIETY, Vol.45(2) : 287-295, 2004 
Journal Title
 JOURNAL OF THE KOREAN OPHTHALMOLOGICAL SOCIETY 
ISSN
 0378-6471 
Issue Date
2004
Keywords
Amniotic membrane ; Excimer laser ; Laminin
Abstract
Purpose: To evaluate the effect of an amniotic membrane transplantation for a corneal epithelial defect that´s due to a excimer laser in rats, and the expression of laminin-5 during cornea reepithelization as compared with a control group. Methods: 40 rats were divided into two groups, the experimental and control groups of 20 rats each. They received a excimer laser on one eye each and a tarsorrhaphy afterward. Preserved human amniotic membranes were transplanted onto the eyes of the experimental group. Immediately after the excimer laser, (at periods of 12, 18, 24, 48, 96 hours after, the excimer laser), the effected eyes were enucleated and a immunohistochemical and indirect immunofluorescein analysis was performed. Results: 12 hours after experiment, the expression of laminin-5 and 2 chains became definite and expression of laminin-5 was also observed in the control group. Expression of the 1 chains were of the same intensity as in the experimental group and in the control group. 24 hours after experiment, a complete corneal´ reepithelization was observed in all eyes and there was no. difference in the expression of laminin between the experimental and control groups. Conclusions: Expression of laminin can definitely be observed early on the corneas of rats that have received a amniotic membrane transplantation after an exposure to a excimer laser, and this expression continued until there was completion of the reepithelization. In the future, the studies about the mechanism of this expression of laminin need to be done.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eung Kweon(김응권) ORCID logo https://orcid.org/0000-0002-1453-8042
Seo, Kyuong Yul(서경률) ORCID logo https://orcid.org/0000-0002-9855-1980
Seong, Gong Je(성공제) ORCID logo https://orcid.org/0000-0002-5456-4296
Lee, Hyung Keun(이형근) ORCID logo https://orcid.org/0000-0002-1123-2136
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111977
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