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뚜렛 장애 아동에서 Risperidone 치료 전후 [123I]IPT SPECT로 측정한 기저 신경절 도파민 운반체 밀도

Other Titles
 Dopamine Transporter Density Assessed with [123I]IPT SPECT Before and After Risperidone Treatment in Children with Tourette's Disorder 
Authors
 윤미진  ;  김재근  ;  천근아  ;  이경열  ;  최태현  ;  지대윤  ;  박세영  ;  류원기  ;  김태훈  ;  유영훈  ;  이종두 
Citation
 Korean Journal of Nuclear Medicine (대한핵의학회지), Vol.38(1) : 41-51, 2004 
Journal Title
 Korean Journal of Nuclear Medicine (대한핵의학회지) 
ISSN
 1225-6714 
Issue Date
2004
Keywords
Tourette's disorder ; Risperidone ; [123I]IPT ; SPECT ; Basal ganglia ; Dopamine transporter
Abstract
Purpose: Tourette´s disorder (TD), which is characterized by multiple waxing and waning motor tics and one or more vocal tics, is known to be associated with abnormalities in the dopaminergic system. To testify our hypothesis that risperidone would improve tic symptoms of TD patients through the change of the dopaminergic system, we measured the dopamine transporter (DAT) densities between drug-naive children with TD and normal children, and investigated the DAT density before and after treatment with risperidone in drug-naive children with TD, using iodine-123 labelled N-(3-iodopropen-2-yl)-2β-carbomethoxy -3beta-(4-chlorophenyl)tropane ([123I]IPT) single photon emission computed tomography (SPECT). MATERIALS and METHODS: [123I]IPT SPECT imaging and Yale Global Tic Severity Scale-Korean version (YGTSS-K) for assessing the tic symptom severity were carried out before and after treatment with risperidone for 8 weeks in nine drug-naive children with TD. Eleven normal children also underwent SPECT imaging 2 hours after an intravenous administration of [123I]IPT. RESULTS: Drug-naive children with TD had a significantly greater increase in the specific/nonspecific DAT binding ratio of both basal ganglia compared with the normal children. However, no significant difference in the specific/nonspecific DAT binding ratio of the basal ganglia before and after treatment with risperidone in children with TD was found, although tic symptoms were significantly improved with risperidone. CONCLUSION: These findings suggest that DAT densities are directly associated with the pathophysiology of TD, however, that the effect of risperidone on tic symptoms in children with TD is not attributed to the change of dopaminergic system.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Tae Hoon(김태훈) ORCID logo https://orcid.org/0000-0003-3598-2529
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Yun, Mi Jin(윤미진) ORCID logo https://orcid.org/0000-0002-1712-163X
Lee, Kyung Yul(이경열) ORCID logo https://orcid.org/0000-0001-5585-7739
Lee, Jong Doo(이종두)
Cheon, Keun Ah(천근아) ORCID logo https://orcid.org/0000-0001-7113-9286
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111936
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