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건강한 성인 남녀에서 Apolipoprotein A-Ⅰ 유전자 다형성과 혈중 지질농도와의 연관성

Other Titles
 The Impact of Apolipoprotein A-I Polymorphisms on the Lipid Profiles in Middle Aged Healthy Men and Women 
Authors
 이종호  ;  이종은  ;  고영국  ;  최성훈  ;  김원호  ;  조은영  ;  문재연  ;  박현영  ;  장양수 
Citation
 KOREAN CIRCULATION JOURNAL, Vol.34(12) : 1158-1166, 2004 
Journal Title
KOREAN CIRCULATION JOURNAL(순환기)
ISSN
 1738-5520 
Issue Date
2004
Keywords
Apolipoprotein A-Ⅰ;Polymorphism;Triglyceride;HDL-cholesterol
Abstract
Background and Objectives:Apolipoprotein A-I is the major lipoprotein constituent of high density lipoprotein in plasma. In this study, the role of two polymorphisms in the apo A-I gene was investigated on the serum lipid profiles and apo A-I levels in healthy men and women.

Subjects and Methods:Blood samples were obtained from 417 subjects (M:F=169:248, mean age 47.2 years). The apo A-I genotypes were determined by SNP-IT assays using the SNPstream 25KTM system.

Results:The frequencies of the A allele at the XmnI restriction site and position -75 bp were 0.25/0.23 and 0.19/0.17 in men and women, respectively. A strong positive linkage disequilibrium (D’=0.990) between two polymorphisms was detected. In men, the A allele at the XmnI restriction site was associated with significantly lower levels of triglyceride (p=0.028) compared to the G/G subjects, but no significant associations were detected between the G-75A polymorphism and any of the lipid traits examined. In women, each A allele for the XmnI restriction site and -75 bp polymorphisms were significantly associated with higher levels of apo A-I (p=0.032 and p=0.012). In the multiple regression analysis, the HDL, being a current drinker and the A allele of the XmnI restriction site polymorphism were major determinants of the serum apo A-I levels in women (R2=0.272, p<0.05).

Conclusion:Our study showed that the A allele at XmnI restriction site in the apo A-I gene was associated with decreased triglyceride levels in men. Each A allele of two polymorphisms was associated with an elevated apo A-I level in women.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Moon, Jae Youn(문재연)
Park, Hyun Young(박현영)
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Cho, Eun Young(조은영)
Choi, Seong Hoon(최성훈)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111781
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