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건강한 성인 남녀에서 Apolipoprotein A-Ⅰ 유전자 다형성과 혈중 지질농도와의 연관성
DC Field | Value | Language |
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dc.contributor.author | 고영국 | - |
dc.contributor.author | 김원호 | - |
dc.contributor.author | 문재연 | - |
dc.contributor.author | 박현영 | - |
dc.contributor.author | 장양수 | - |
dc.contributor.author | 조은영 | - |
dc.contributor.author | 최성훈 | - |
dc.date.accessioned | 2015-07-14T16:53:07Z | - |
dc.date.available | 2015-07-14T16:53:07Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1738-5520 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111781 | - |
dc.description.abstract | Background and Objectives:Apolipoprotein A-I is the major lipoprotein constituent of high density lipoprotein in plasma. In this study, the role of two polymorphisms in the apo A-I gene was investigated on the serum lipid profiles and apo A-I levels in healthy men and women. Subjects and Methods:Blood samples were obtained from 417 subjects (M:F=169:248, mean age 47.2 years). The apo A-I genotypes were determined by SNP-IT assays using the SNPstream 25KTM system. Results:The frequencies of the A allele at the XmnI restriction site and position -75 bp were 0.25/0.23 and 0.19/0.17 in men and women, respectively. A strong positive linkage disequilibrium (D’=0.990) between two polymorphisms was detected. In men, the A allele at the XmnI restriction site was associated with significantly lower levels of triglyceride (p=0.028) compared to the G/G subjects, but no significant associations were detected between the G-75A polymorphism and any of the lipid traits examined. In women, each A allele for the XmnI restriction site and -75 bp polymorphisms were significantly associated with higher levels of apo A-I (p=0.032 and p=0.012). In the multiple regression analysis, the HDL, being a current drinker and the A allele of the XmnI restriction site polymorphism were major determinants of the serum apo A-I levels in women (R2=0.272, p<0.05). Conclusion:Our study showed that the A allele at XmnI restriction site in the apo A-I gene was associated with decreased triglyceride levels in men. Each A allele of two polymorphisms was associated with an elevated apo A-I level in women. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1158~1166 | - |
dc.relation.isPartOf | KOREAN CIRCULATION JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 건강한 성인 남녀에서 Apolipoprotein A-Ⅰ 유전자 다형성과 혈중 지질농도와의 연관성 | - |
dc.title.alternative | The Impact of Apolipoprotein A-I Polymorphisms on the Lipid Profiles in Middle Aged Healthy Men and Women | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | 이종호 | - |
dc.contributor.googleauthor | 이종은 | - |
dc.contributor.googleauthor | 고영국 | - |
dc.contributor.googleauthor | 최성훈 | - |
dc.contributor.googleauthor | 김원호 | - |
dc.contributor.googleauthor | 조은영 | - |
dc.contributor.googleauthor | 문재연 | - |
dc.contributor.googleauthor | 박현영 | - |
dc.contributor.googleauthor | 장양수 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J01953 | - |
dc.identifier.eissn | 1738-5555 | - |
dc.subject.keyword | Apolipoprotein A-Ⅰ;Polymorphism;Triglyceride;HDL-cholesterol | - |
dc.contributor.alternativeName | Ko, Young Guk | - |
dc.contributor.alternativeName | Kim, Won Ho | - |
dc.contributor.alternativeName | Moon, Jae Youn | - |
dc.contributor.alternativeName | Park, Hyun Young | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.alternativeName | Cho, Eun Young | - |
dc.contributor.alternativeName | Choi, Seong Hoon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 34 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1158 | - |
dc.citation.endPage | 1166 | - |
dc.identifier.bibliographicCitation | KOREAN CIRCULATION JOURNAL, Vol.34(12) : 1158-1166, 2004 | - |
dc.identifier.rimsid | 37465 | - |
dc.type.rims | ART | - |
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