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The pattern of gene copy number changes in bilateral breast cancer surveyed by cDNA microarray-based comparative genomic hybridization.

DC FieldValueLanguage
dc.contributor.author라선영-
dc.contributor.author박병우-
dc.contributor.author박찬희-
dc.contributor.author서민영-
dc.contributor.author안중배-
dc.contributor.author양상화-
dc.contributor.author양우익-
dc.contributor.author이귀연-
dc.contributor.author정현철-
dc.date.accessioned2015-07-14T16:51:24Z-
dc.date.available2015-07-14T16:51:24Z-
dc.date.issued2004-
dc.identifier.issn1107-3756-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/111726-
dc.description.abstractThe nature of genetic alterations in bilateral breast cancer (BBC) associated with the distinctive development of a second primary tumor or a metastatic lesion is not clearly established. In this study, patterns of promoter methylation and gene copy number changes were assessed for their utility in the distinction of two types of BBC (synchronous and metachronous). Seven cases of synchronous and five cases of metachronous breast cancer tissues were used in X chromosome inactivation assay to assess the methylation pattern of human androgen receptor gene. X chromosome inactivation assay alone did not provide enough information to distinguish the genetic origins of synchronous and metachronous BBC. When four pairs of paraffin-embedded BBC tissues were used in cDNA array-based CGH with placenta DNA as a reference, higher DNA copy number changes were observed from metachronous pairs (9.0%) than from synchronous pairs (3.1%). From the two cases of metachronous pairs tested, 44 genes were found to be commonly modulated in gene copy numbers in a cancer detected later.-
dc.description.statementOfResponsibilityopen-
dc.format.extent17~24-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF MOLECULAR MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBreast Neoplasms/genetics*-
dc.subject.MESHChromosomes, Human, X*-
dc.subject.MESHDNA, Complementary-
dc.subject.MESHDosage Compensation, Genetic-
dc.subject.MESHFemale-
dc.subject.MESHGene Dosage*-
dc.subject.MESHHumans-
dc.subject.MESHNucleic Acid Hybridization-
dc.subject.MESHOligonucleotide Array Sequence Analysis-
dc.titleThe pattern of gene copy number changes in bilateral breast cancer surveyed by cDNA microarray-based comparative genomic hybridization.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorMin Young Seo-
dc.contributor.googleauthorSun Young Rha-
dc.contributor.googleauthorHyun Cheol Chung-
dc.contributor.googleauthorByung Woo Park-
dc.contributor.googleauthorJoong Bae Ahn-
dc.contributor.googleauthorWoo Ick Yang-
dc.contributor.googleauthorChan Hee Park-
dc.contributor.googleauthorGui Youn Lee-
dc.contributor.googleauthorSang Cheol Kim-
dc.contributor.googleauthorSang Hwa Yang-
dc.identifier.doi10.3892/ijmm.13.1.17-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.relation.journalcodeJ01132-
dc.identifier.eissn1791-244X-
dc.identifier.pmid14654965-
dc.identifier.urlhttp://www.spandidos-publications.com/ijmm/13/1/17-
dc.contributor.alternativeNameRha, Sun Young-
dc.contributor.alternativeNamePark, Byeong Woo-
dc.contributor.alternativeNamePark, Chan Hee-
dc.contributor.alternativeNameSeo, Min Young-
dc.contributor.alternativeNameAhn, Joong Bae-
dc.contributor.alternativeNameYang, Sang Hwa-
dc.contributor.alternativeNameYang, Woo Ick-
dc.contributor.alternativeNameLee, Gui Youn-
dc.contributor.alternativeNameChung, Hyun Cheol-
dc.rights.accessRightsnot free-
dc.citation.volume13-
dc.citation.number1-
dc.citation.startPage17-
dc.citation.endPage24-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, Vol.13(1) : 17-24, 2004-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers
5. Research Institutes (연구소) > Cancer Metastasis Research Center (암전이연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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