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Levodopa-responsive parkinsonism in hereditary spastic paraplegia with thin corpus callosum

Authors
 Suk Y. Kang  ;  Mee H. Lee  ;  Seung K. Lee  ;  Young H. Sohn 
Citation
 PARKINSONISM & RELATED DISORDERS, Vol.10(7) : 425-427, 2004 
Journal Title
 PARKINSONISM & RELATED DISORDERS 
ISSN
 1353-8020 
Issue Date
2004
MeSH
Adolescent ; Antiparkinson Agents/therapeutic use* ; Benztropine/therapeutic use ; Cognition Disorders/etiology ; Cognition Disorders/physiopathology ; Corpus Callosum/pathology* ; Electroencephalography ; Female ; Gait Disorders, Neurologic/etiology ; Gait Disorders, Neurologic/physiopathology ; Humans ; Levodopa/therapeutic use* ; Magnetic Resonance Imaging ; Male ; Muscle Weakness/etiology ; Muscle Weakness/physiopathology ; Neuropsychological Tests ; Parkinson Disease/drug therapy* ; Parkinson Disease/etiology* ; Selegiline/therapeutic use ; Spastic Paraplegia, Hereditary/complications* ; Spastic Paraplegia, Hereditary/pathology ; Tremor/etiology ; Tremor/physiopathology
Keywords
Spastic paraplegia ; Corpus callosum ; Parkinsonism ; Heredity ; Levodopa
Abstract
Hereditary spastic paraplegia with thin corpus callosum is a rare degenerative disease, which is characterized by a progressive weakness of the lower limbs with a hypoplastic corpus callosum, and is often associated with other symptoms such as mental impairment, amyotrophy, sensory disturbances, dysuria, nystagmus and cataract. We describe two siblings (brother and sister) who showed a thin corpus callosum on MRI, one of whom showed the pure form of progressive spastic paraplegia, while the other showed predominant levodopa-responsive parkinsonism. The present cases are illustrative of a phenotypic heterogeneity in the same family of spastic paraplegia with a thin corpus callosum, despite the identical neuroimaging findings, and also presented another form of autosomal recessive juvenile levodopa-responsive parkinsonism.
Full Text
http://www.sciencedirect.com/science/article/pii/S1353802004000884
DOI
10.1016/j.parkreldis.2004.05.003
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111710
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