0 505

Cited 16 times in

Significance of chronic epilepsy in glial tumors and correlation with surgical strategies

Authors
 Ok-Joon Kim  ;  Jung Yong Ahn  ;  Byung-In Lee  ;  Joong Uhn Choi  ;  Kyu Sung Lee  ;  Sang Sup Chung  ;  Young Sun Chung 
Citation
 JOURNAL OF CLINICAL NEUROSCIENCE, Vol.11(7) : 702-705, 2004 
Journal Title
JOURNAL OF CLINICAL NEUROSCIENCE
ISSN
 0967-5868 
Issue Date
2004
MeSH
Adult ; Brain Neoplasms/complications* ; Brain Neoplasms/surgery ; Chronic Disease ; Epilepsy/etiology* ; Female ; Glioma/complications* ; Glioma/surgery* ; Humans ; Male ; Neurosurgical Procedures/adverse effects* ; Postoperative Period ; Prognosis ; Treatment Outcome
Keywords
brain neoplasms ; glioma ; epilepsy ; surgical strategies
Abstract
PURPOSE: This study was designed to compare the frequency of postoperative epilepsy in patients with acute and chronic pre-operative epilepsy and with frontal or temporal lobe glial tumors based on the hypothesis that patients with chronic epilepsy do worse.
METHODS: We compared the clinical and diagnostic characteristics of the patients (n = 73) who had seizures preoperatively with those of the patients (n = 153) who did not. Among those who have had seizures preoperatively, we compared those (n = 32, chronic seizure group) who had seizures a year or more prior to surgery with those (n = 41, acute seizure group) who had seizures less than a year prior to surgery.
RESULTS: Among the various factors, the frequency of benign pathology and favorable neurological state were higher in the seizure group than in the non-seizure group (p < 0.05). Complex partial seizures and low-grade tumors were frequent in the chronic seizure group, whereas simple partial seizures and high-grade tumors were frequent in the acute seizure group. Seizure-free rate was significantly higher in the acute seizure group than in the chronic group (p < 0.05). Also, the difference of seizure control rate between surgical strategies was statistically significant (p < 0.05).
CONCLUSION: This study indicates that preoperative seizure duration and frequency have a close relationship with the frequency of postoperative epilepsy in patients with glial tumors. A longer duration may allow the formation of epileptogenic foci, leading to chronic epilepsy, and eventually have a negative effect on the prognosis of the patients. Factors including histopathological characteristics of the tumor, its location, seizure duration/frequency, and symptomatology should be taken into account when deciding on surgical strategies.
Full Text
http://www.sciencedirect.com/science/article/pii/S0967586804001535
DOI
10.1016/j.jocn.2003.09.018
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Kyu Sung(이규성)
Lee, Byung In(이병인)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/111693
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links