1 380

Cited 12 times in

Simultaneous acquisition of perfusion and permeability from corrected relaxation rates with dynamic susceptibility contrast dual gradient echo

 Eun-Ju Kim  ;  Dae-Hong Kim  ;  Jin-Suck Suh  ;  Ho-Taek Song  ;  Yong-Min Huh  ;  Sang Hoon Lee 
 MAGNETIC RESONANCE IMAGING, Vol.22(3) : 307-314, 2004 
Journal Title
Issue Date
Algorithms ; Blood Vessels/metabolism ; Blood Volume ; Contrast Media/chemistry* ; Contrast Media/pharmacokinetics ; Extravasation of Diagnostic and Therapeutic Materials ; Gadolinium DTPA/chemistry* ; Gadolinium DTPA/pharmacokinetics ; Image Enhancement ; Magnetic Resonance Imaging/instrumentation ; Magnetic Resonance Imaging/methods* ; Models, Biological ; Perfusion* ; Permeability* ; Phantoms, Imaging*
Perfusion ; Permeability ; Dual gradient echo ; Corrected relaxation rates
This study compared two methods, corrected (separation of T1 and T2 effects) and uncorrected, in order to determine the suitability of the perfusion and permeability measures through ΔR2 and ΔR1 analyses. A dynamic susceptibility contrast dual gradient echo (DSC-DGE) was used to image the fixed phantoms and flow phantoms (Sephadex perfusion phantoms and dialyzer phantom for the permeability measurements). The results confirmed that the corrected relaxation rate was linearly proportional to gadolinium-diethyltriamine pentaacetic acid (Gd-DTPA) concentration, whereas the uncorrected relaxation rate did not in the fixed phantom and simulation experiments. For the perfusion measurements, it was found that the correction process was necessary not only for the ΔR1 time curve but also for the ΔR2 time curve analyses. Perfusion could not be measured without correcting the ΔR2 time curve. The water volume, which was expressed as the perfusion amount, was found to be closer to the theoretical value when using the corrected ΔR1 curve in the calculations. However, this may occur in the low concentration of Gd-DTPA in tissue used in this study. For the permeability measurements based on the two-compartment model, the permeability factor (kev; e = extravascular, v = vascular) from the outside to the inside of the hollow fibers was greater in the corrected ΔR1 method than in the uncorrected ΔR1 method. The differences between the corrected and the uncorrected ΔR1 values were confirmed by the simulation experiments. In conclusion, this study proposes that the correction for the relaxation rates, ΔR2 and ΔR1, is indispensable in making accurate perfusion and permeability measurements, and that DSC-DGE is a useful method for obtaining information on perfusion and permeability, simultaneously.
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Song, Ho Taek(송호택) ORCID logo https://orcid.org/0000-0002-6655-2575
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.