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맥락얼기 뇌실막세포이식이 척수 손상 흰쥐의 신경재생에 미치는 영향

Other Titles
 the Effect of Ependymal Cell Transplantation on Nerve Regeneration after Spinal Cord Injury in Rats 
 이원택  ;  오형석  ;  박경아  ;  이종은  ;  안수경  ;  김재환  ;  정효석 
 Korean Journal of Anatomy (대한해부학회지), Vol.37(6) : 529-538, 2004 
Journal Title
 Korean Journal of Anatomy (대한해부학회지) 
Issue Date
맥락얼기 뇌실막세포 ; 척수손상 ; 신경재생 ; Choroid plexus ependymal cell ; Spinal cord injury ; Nerve regeneration
Nerve regeneration in the central nervous system has been studied by grafting various tissues and cells. Choroid plexus epithelial cells represent a continuation of ventricular ependymal cells and have the same origin as regarded as modified ependymal cells. To study the use of choroid plexus ependymal cell grafting for nerve regeneration in the spinal cord, the choroid plexus was excised from the lateral and fourth ventricles of adult Sprague-Dawley rats, minced into small fragments, and grafted at the T9 level in adult rat spinal cord transected or contused. In this study, transplants of choroid plexus ependymal cells were successfully used to promote functional and structural recovery after spinal cord transection and contusion. The area of damaged spinal cord was diminished after choroid plexus ependymal cells transplantation. Nearly normal anterior horn cells were observed immediately distal to the transected region. Tyrosine hydroxylase immunoreactive descending fibers were observed in the distal region beyond transected area. These findings indicate that choroid plexus ependymal cells have the ability to facilitate axonal growth, suggesting that they may be a promising candidate as graft for the promotion of nerve regeneration in the spinal cord.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Park, Kyung Ah(박경아)
Ahn, Soo Kyung(안수경)
Lee, Won Taek(이원택) ORCID logo https://orcid.org/0000-0001-7348-9562
Lee, Jong Eun(이종은) ORCID logo https://orcid.org/0000-0001-6203-7413
Jeong, Hyo Seok(정효석)
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