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Gamma Knife Radiosurgery for Remnant or Recurred Craniopharyngiomas

 Young Sub Kwon  ;  Yong Sook Park  ;  Jong Hee Chang  ;  Jin Woo Chang  ;  Yong Gou Park 
 Journal of Korean Neurosurgical Society (대한신경외과학회지), Vol.39(2) : 96-101, 2006 
Journal Title
Journal of Korean Neurosurgical Society(대한신경외과학회지)
Issue Date
Radiosurgery ; Gamma knife ; Craniopharyngioma ; Optic apparatus
Objective:The authors assess the long term effectiveness of gamma knife radiosurgery(GKS) for remnant or recurred craniopharyngiomas on tumor control and possibly set proper radiation dose for tumor control with utmost preservation of the adjacent structures.

Methods : Sixteen GKS were done in 14 patients with recurred or remnant craniopharyngiomas after surgery. Mean follow up duration was 44.2 months (range 11.3~123.6 months). Follow up MR imagings were analyzed.

Results : Mean tumor volume was 3.6cm3 (range 0.6~18cm3) and mean margin dose was 12.2Gy (range 8~22.4Gy). Tumor control was achieved in 87.5% (14 of 16 tumors) which were either solid or cystic in nature. Dose to optic apparatus was mean 7.9Gy and no radiation related complications were observed.

Conclusion : GKS seems to be effective treatment modality for craniopharyngiomas regardless of nature of tumor whether it is cystic or solid. Dose of 8 to 8.5Gy may be sufficient to achieve long term tumor control for remnant or recurred craniopharyngiomas.
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1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Young Sub(권영섭)
Park, Yong Gou(박용구)
Park, Yong Sook(박용숙)
Chang, Jong Hee(장종희) ORCID logo https://orcid.org/0000-0003-1509-9800
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
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