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Botulinum Toxin Type A Injection for Management of Upper Limb Spasticity in Children with Cerebral Palsy: a Literature Review

Authors
 Eun Sook Park  ;  Dong-wook Rha 
Citation
 YONSEI MEDICAL JOURNAL, Vol.47(5) : 589-603, 2006 
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
 0513-5796 
Issue Date
2006
MeSH
Adolescent ; Adult ; Age Factors ; Botulinum Toxins, Type A/administration & dosage ; Botulinum Toxins, Type A/therapeutic use* ; Cerebral Palsy/drug therapy* ; Child ; Child, Preschool ; Humans ; Infant ; Injections ; Muscle Spasticity/drug therapy ; Neuromuscular Agents/administration & dosage ; Neuromuscular Agents/therapeutic use* ; Range of Motion, Articular/drug effects ; Upper Extremity
Keywords
Cerebral palsy ; botulinum toxin type A ; spasticity ; upper limb
Abstract
The aim of this article was to present a review of the research literature on the outcome of botulinum toxin type A (BTX-A) injection for management of upper limb spasticity in children with cerebral palsy (CP). We searched the electronic databases of MEDLINE, CINAHL and PUBMED for all published studies with full-length English text available. For each study, the quality of the methods and the strength of evidence were assessed by 2 independent reviewers based on the American Academy for Cerebral Palsy and Developmental Medicine (AACPDM) guidelines. Four studies of level I, 8 studies of level IV and 4 studies of level V were identified. Due to the limited number of studies with high quality evidence and inconsistent results among studies, we were unable to support or refute the usefulness of BTX-A injection for management of upper limb spasticity in children with CP. Moreover, we identified several variables that may affect the outcome of injection, such as timing of age, dosage, dilution volumes, localization techniques of target muscles and participant characteristics. In summary, we have presented a review the literature and a discussion of the considerable uncertainty and variation associated with the clinical use of BTX-A injection for management of upper limb spasticity in children with CP.
Files in This Item:
T200604413.pdf Download
DOI
10.3349/ymj.2006.47.5.589
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Rha, Dong Wook(나동욱) ORCID logo https://orcid.org/0000-0002-7153-4937
Park, Eun Sook(박은숙) ORCID logo https://orcid.org/0000-0002-9144-3063
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/110977
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