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Prevalence of inducible clindamycin resistance in staphylococcal isolates at a Korean Tertiary Care Hospital

Authors
 Hwan Sub Lim  ;  Hyukmin Lee  ;  Kyoung Ho Roh  ;  Jong Hwa Yum  ;  Dongeun Yong  ;  Kyungwon Lee  ;  Yunsop Chong 
Citation
 YONSEI MEDICAL JOURNAL, Vol.47(4) : 480-484, 2006 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2006
MeSH
Anti-Bacterial Agents/pharmacology* ; Anti-Infective Agents/pharmacology* ; Clindamycin/pharmacology* ; Drug Resistance, Microbial* ; Drug Resistance, Multiple, Bacterial ; Humans ; Korea ; Microbial Sensitivity Tests* ; Prevalence ; Staphylococcal Infections/metabolism* ; Staphylococcus aureus/metabolism
Keywords
Staphylococcus ; clindamycin ; antibiotic resistance
Abstract
Clindamycin resistance in Staphylococcus species can be either constitutive or inducible. Inducible resistance cannot be detected by the conventional antimicrobial susceptibility test. In this study, we determined the prevalence of inducible clindamycin resistance in staphylococcal isolates at a Korean tertiary care hospital. Between February and September 2004, 1,519 isolates of Staphylococcus aureus and 1,043 isolates of coagulase-negative staphylococci (CNS) were tested for inducible resistance by the D-zone test. Overall, 17% of MRSA, 84% of MSSA, 37% of MRCNS, and 70% of MSCNS were susceptible to clindamycin. Of the erythromycin non-susceptible, clindamycin-susceptible isolates, 32% of MRSA, 35% of MSSA, 90% of MRCNS, and 94% of MSCNS had inducible clindamycin resistance. Inducible clindamycin resistance in staphylococci was highly prevalent in Korea. This study indicates importance of the D-zone test in detecting inducible clindamycin resistance in staphylococci to aid in the optimal treatment of patients.
Files in This Item:
T200603818.pdf Download
DOI
10.3349/ymj.2006.47.4.480
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Research Institute of Bacterial Resistance (세균내성연구소) > 1. Journal Papers
Yonsei Authors
Yum, Jong Hwa(염종화)
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/110910
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