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A Phase II Study of Infusional 5-Fluorouracil and Low-Dose Leucovorin with Docetaxel for Advanced Gastric Cancer

Authors
 Jeung H.-C.  ;  Rha S.Y.  ;  Kim Y.T.  ;  Noh S.H.  ;  Roh J.K.  ;  Chung H.C. 
Citation
 ONCOLOGY, Vol.70(1) : 63-70, 2006 
Journal Title
 ONCOLOGY 
ISSN
 0030-2414 
Issue Date
2006
MeSH
Adenocarcinoma/drug therapy* ; Adenocarcinoma/secondary ; Adult ; Aged ; Antimetabolites, Antineoplastic/administration & dosage ; Antineoplastic Agents/therapeutic use* ; Antineoplastic Agents, Phytogenic/administration & dosage ; Docetaxel ; Female ; Fluorouracil/administration & dosage ; Humans ; Infusions, Intravenous ; Leucovorin/administration & dosage ; Male ; Middle Aged ; Stomach Neoplasms/drug therapy* ; Stomach Neoplasms/pathology ; Survival Analysis ; Taxoids/administration & dosage ; Treatment Outcome
Keywords
Docetaxel ; 5-Fluorouracil ; Leucovorin ; Gastric cancer
Abstract
BACKGROUND: The standard chemotherapy regimen for advanced gastric cancer has not yet been established. We investigated the efficacy and the safety of the combination of docetaxel with infusional 5-fluorouracil (5-FU) and leucovorin (FLT) in advanced gastric cancer. METHODS: Patients received docetaxel 75 mg/m(2) (1-hour infusion) followed by a leucovorin bolus 20 mg/m(2) and a 24-hour infusion of 5-FU 1,000 mg/m(2) (day 1-3) every 3 weeks. The response was evaluated according to the Response Evaluation Criteria in Solid Tumors (RECIST) criteria, and the toxicity was evaluated by National Cancer Institute common toxicity criteria (NCI-CTC). RESULTS: Sixty-six patients were enrolled. Median relative dose intensity was 86%. Of 57 evaluable patients, the overall response rate was 25.7%. The response rate was 34.2% in chemonaïve patients and 14.2% in the patients who had previously received treatment. Median time to progression and overall survival duration were 5.2 and 9.7 months, respectively. The most frequent grade 3-4 toxicity was neutropenia, which was the major cause of treatment delay. Other hematological and nonhematological toxicities were rare. CONCLUSIONS: The FLT regimen showed a comparable efficacy with other second-generation regimens. Because of the low nonhematological toxicity, this could be a potential alternative to the cisplatin-containing regimens in gastric cancer.
Full Text
http://www.karger.com/Article/FullText/91186
DOI
10.1159/000091186
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Roh, Jae Kyung(노재경)
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
Jeung, Hei Cheul(정희철) ORCID logo https://orcid.org/0000-0003-0952-3679
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/110876
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