Detection of hepatic metastasis: Manganese- and ferucarbotran-enhanced MR imaging
Authors
Jin-Young Choi ; Myeong-Jin Kim ; Joo Hee Kim ; Seung Hyoung Kim ; Heung-Kyu Ko ; Joon Seok Lim ; Young Taik Oh ; Jae-Joon Chung ; Hyung Sik Yoo ; Jong Tae Lee ; Ki Whang Kim
Citation
EUROPEAN JOURNAL OF RADIOLOGY, Vol.60(1) : 84-90, 2006
PURPOSE: To compare the mangafodipir trisodium (MnDPDP)-enhanced and ferucarbotran-enhanced magnetic resonance imaging (MRI) for the detection of hepatic metastases.
MATERIAL AND METHODS: Twenty patients with known hepatic metastasis underwent MR imaging using mangafodipir trisodium and ferucarbotran in at least 1-day intervals. Thirty-eight metastases were confirmed either histologically or clinically. Two radiologists independently reviewed the MnDPDP-enhanced and ferucarbotran-enhanced sets in a random order. The sensitivity and accuracy of lesion detection and the ability to distinguish a benign lesion from a malignant lesion were compared by the areas (Az) under the receiver operating characteristic (ROC) curve. The lesion-liver contrast-to-noise ratios (CNR) were compared by paired t-test.
RESULTS: The overall accuracy for detecting metastases was not significantly different between the MnDPDP set (Az=0.912 and 0.913 for reader 1 and 2, respectively) and the SPIO set (Az=0.920 and 0.950). The CNR at the MnDPDP-enhanced images and the SPIO-enhanced images were not significantly different (P=0.146).
CONCLUSION: Both MnDPDP- and ferucarbotran-enhanced MRI have a comparable accuracy in detecting hepatic metastasis