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Improved Attachment and Proliferation of Porcine Articular Chondrocyte onto Hydroxyapatite Incorporated Poly(Lactic-co-Glycolic acid)

Authors
 J. B. Lee  ;  S. G. Lee  ;  S. M. Yoo  ;  J. -C. Park  ;  J. B. Choi  ;  J. K. Kim 
Citation
 Biomaterials Research (생체재료학회지), Vol.10(4) : 196-200, 2006 
Journal Title
 Biomaterials Research (생체재료학회지) 
ISSN
 1226-1226 
Issue Date
2006
Keywords
Poly (lactic–co–glycolic acid) ; Hydroxyapatite incorporation ; Chondrocyte ; Attachment ; Proliferation
Abstract
Hydroxyapatite (HA) powders were incorporated in PLGA (75 : 25) films to investigate the effect of various HA contents in the composite film to the attachment and proliferation of porcine chondrocyte. The films were prepared by solvent-casting method. We observed the mechanical properties of the composite as well as chondrocyte attachment and proliferation of the prepared specimens. The 10 wt% HA content film showed two-fold higher ultimate tensile strength than control group. In surface characterization of the film, the surface of HA/PLGA composite films were more hydrophilic than that of control group (p<0.05). The cell attachment and cell proliferation of the HA/PLGA composite films (10 wt % HA) showed significantly higher than those of control group (1.44 times higher in attachment test, and 1.31 times higher at 6th-day of culture in proliferation assaying, p<0.05). Based on these findings, 10 wt% of HA content in PLGA film was effective on improving mechanical properties as well as cultivating conditions for porcine chondrocyte.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
Lee, Sang Kil(이상길) ORCID logo https://orcid.org/0000-0002-0721-0364
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/110847
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