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Improved Attachment and Proliferation of Porcine Articular Chondrocyte onto Hydroxyapatite Incorporated Poly(Lactic-co-Glycolic acid)
DC Field | Value | Language |
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dc.contributor.author | 박종철 | - |
dc.contributor.author | 이상길 | - |
dc.date.accessioned | 2015-06-10T13:00:43Z | - |
dc.date.available | 2015-06-10T13:00:43Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1226-1226 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/110847 | - |
dc.description.abstract | Hydroxyapatite (HA) powders were incorporated in PLGA (75 : 25) films to investigate the effect of various HA contents in the composite film to the attachment and proliferation of porcine chondrocyte. The films were prepared by solvent-casting method. We observed the mechanical properties of the composite as well as chondrocyte attachment and proliferation of the prepared specimens. The 10 wt% HA content film showed two-fold higher ultimate tensile strength than control group. In surface characterization of the film, the surface of HA/PLGA composite films were more hydrophilic than that of control group (p<0.05). The cell attachment and cell proliferation of the HA/PLGA composite films (10 wt % HA) showed significantly higher than those of control group (1.44 times higher in attachment test, and 1.31 times higher at 6th-day of culture in proliferation assaying, p<0.05). Based on these findings, 10 wt% of HA content in PLGA film was effective on improving mechanical properties as well as cultivating conditions for porcine chondrocyte. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 196~200 | - |
dc.relation.isPartOf | Biomaterials Research (생체재료학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Improved Attachment and Proliferation of Porcine Articular Chondrocyte onto Hydroxyapatite Incorporated Poly(Lactic-co-Glycolic acid) | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Medical Engineering (의학공학) | - |
dc.contributor.googleauthor | J. B. Lee | - |
dc.contributor.googleauthor | S. G. Lee | - |
dc.contributor.googleauthor | S. M. Yoo | - |
dc.contributor.googleauthor | J. -C. Park | - |
dc.contributor.googleauthor | J. B. Choi | - |
dc.contributor.googleauthor | J. K. Kim | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01662 | - |
dc.contributor.localId | A02812 | - |
dc.relation.journalcode | J00314 | - |
dc.subject.keyword | Poly (lactic–co–glycolic acid) | - |
dc.subject.keyword | Hydroxyapatite incorporation | - |
dc.subject.keyword | Chondrocyte | - |
dc.subject.keyword | Attachment | - |
dc.subject.keyword | Proliferation | - |
dc.contributor.alternativeName | Park, Jong Chul | - |
dc.contributor.alternativeName | Lee, Sang Kil | - |
dc.contributor.affiliatedAuthor | Park, Jong Chul | - |
dc.contributor.affiliatedAuthor | Lee, Sang Kil | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 10 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 196 | - |
dc.citation.endPage | 200 | - |
dc.identifier.bibliographicCitation | Biomaterials Research (생체재료학회지), Vol.10(4) : 196-200, 2006 | - |
dc.identifier.rimsid | 54481 | - |
dc.type.rims | ART | - |
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