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G-CSF Mobilized Peripheral Blood Human Hematopoietic CD34+ Stem Cells Therapy for Acute Stroke: Preliminary Results

Authors
 Jung Yong Ahn  ;  In Bo Han  ;  Dong Ku Kim 
Citation
 Korean Journal of Cerebrovascular Surgery (대한뇌혈관외과학회지), Vol.8(4) : 235-240, 2006 
Journal Title
 Korean Journal of Cerebrovascular Surgery (대한뇌혈관외과학회지) 
ISSN
 1738-0499 
Issue Date
2006
Keywords
Acute stroke ; Cell transplantation ; Hematopoietic stem cells ; CD34 ; Vascular endothelial growth factor
Abstract
Objective:Acute stroke caused by cerebral artery occlusion or rupture is the most important vascular central nervous system disorder in Korea and remains a leading cause of death and disability despite significant clinical benefits after current treatment modalities. Therefore, it is crucial to develop new alternative therapeutic strategies. The most encouraging approach is directed towards cell transplantation into damaged regions. We discuss the ideal candidate for cell transplantation in current status and preliminary results of peripheral blood stem cells transplantation for acute stroke. Methods : Five patients with acute stroke (three patients with deep intracerebral hemorrhage and two patients with middle cerebral artery occlusion) underwent peripheral blood stem cells transplantation stereotactically. Results : Cell transplantation of three patients did not improve motor function recovery, as evidenced by NIHSS. However, interestingly, cell transplantation significantly increased CSF levels of vascular endothelial growth factor (VEGF). Conclusion : Cell transplantation did correlate positively with elevated growth factor levels in CSF, but not with improved motor function.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Goo(김동구)
Ahn, Jung Yong(안정용)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/110669
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