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G-CSF Mobilized Peripheral Blood Human Hematopoietic CD34+ Stem Cells Therapy for Acute Stroke: Preliminary Results

DC FieldValueLanguage
dc.contributor.author김동구-
dc.contributor.author안정용-
dc.date.accessioned2015-06-10T12:54:38Z-
dc.date.available2015-06-10T12:54:38Z-
dc.date.issued2006-
dc.identifier.issn1738-0499-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/110669-
dc.description.abstractObjective:Acute stroke caused by cerebral artery occlusion or rupture is the most important vascular central nervous system disorder in Korea and remains a leading cause of death and disability despite significant clinical benefits after current treatment modalities. Therefore, it is crucial to develop new alternative therapeutic strategies. The most encouraging approach is directed towards cell transplantation into damaged regions. We discuss the ideal candidate for cell transplantation in current status and preliminary results of peripheral blood stem cells transplantation for acute stroke. Methods : Five patients with acute stroke (three patients with deep intracerebral hemorrhage and two patients with middle cerebral artery occlusion) underwent peripheral blood stem cells transplantation stereotactically. Results : Cell transplantation of three patients did not improve motor function recovery, as evidenced by NIHSS. However, interestingly, cell transplantation significantly increased CSF levels of vascular endothelial growth factor (VEGF). Conclusion : Cell transplantation did correlate positively with elevated growth factor levels in CSF, but not with improved motor function.-
dc.description.statementOfResponsibilityopen-
dc.format.extent235~240-
dc.relation.isPartOfKorean Journal of Cerebrovascular Surgery (대한뇌혈관외과학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleG-CSF Mobilized Peripheral Blood Human Hematopoietic CD34+ Stem Cells Therapy for Acute Stroke: Preliminary Results-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pharmacology (약리학)-
dc.contributor.googleauthorJung Yong Ahn-
dc.contributor.googleauthorIn Bo Han-
dc.contributor.googleauthorDong Ku Kim-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00396-
dc.contributor.localIdA02260-
dc.relation.journalcodeJ01975-
dc.subject.keywordAcute stroke-
dc.subject.keywordCell transplantation-
dc.subject.keywordHematopoietic stem cells-
dc.subject.keywordCD34-
dc.subject.keywordVascular endothelial growth factor-
dc.contributor.alternativeNameKim, Dong Goo-
dc.contributor.alternativeNameAhn, Jung Yong-
dc.contributor.affiliatedAuthorKim, Dong Goo-
dc.contributor.affiliatedAuthorAhn, Jung Yong-
dc.rights.accessRightsfree-
dc.citation.volume8-
dc.citation.number4-
dc.citation.startPage235-
dc.citation.endPage240-
dc.identifier.bibliographicCitationKorean Journal of Cerebrovascular Surgery (대한뇌혈관외과학회지), Vol.8(4) : 235-240, 2006-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers

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