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Role of Mitogen-Activated Protein Kinases, NF-κB, and AP-1 on Cerulein-Induced IL-8 Expression in Pancreatic Acinar Cells

Authors
 KYUNG DON JU  ;  JI HOON YU  ;  HYEYOUNG KIM  ;  KYUNG HWAN KIM 
Citation
 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, Vol.1090 : 368-374, 2006 
Journal Title
 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 
ISSN
 0077-8923 
Issue Date
2006
MeSH
Animals ; Base Sequence ; Cell Line ; Ceruletide/pharmacology* ; DNA Primers ; Interleukin-8/metabolism* ; Mitogen-Activated Protein Kinases/antagonists & inhibitors ; Mitogen-Activated Protein Kinases/metabolism* ; NF-kappa B/metabolism* ; Pancreas/cytology ; Pancreas/drug effects* ; Pancreas/enzymology ; Pancreas/metabolism ; Protein Kinase Inhibitors/pharmacology ; Rats ; Reverse Transcriptase Polymerase Chain Reaction ; Transcription Factor AP-1/metabolism*
Keywords
cerulein ; IL‐8 ; AR42J cells ; mitogen‐activated protein kinases ; NF‐κB ; AP‐1
Abstract
The cholecystokine (CCK) analogue cerulein causes pathophysiological, morphological, and biochemical events similar to various aspects of human pancreatitis. Doses of CCK or cerulein beyond those that cause the maximum pancreatic secretion of amylase and lipase result in pancreatitis, which is characterized by a dysregulation of the digestive enzyme production and cytoplasmic vacuolization and the death of acinar cells, edema formation, and an infiltration of inflammatory cells into the pancreas. This study aims to investigate whether cerulein induces IL-8 expression in pancreatic acinar cells, and whether cerulein-induced IL-8 expression is inhibited in the cells transfected with mutant genes for c-jun (TAM-67), or IκBα (MAD-3) or treated inhibitors of mitogen-activated protein kinases (MAPKs). As a result, cerulein induced IL-expression, which was inhibited in the cells transfected with TAM-67 or MAD-3 or treated inhibitors of MAPK. In conclusion, activation of MAPK, nuclear factor-κB (NF-κB), and activator protein-1 (AP-1) may be the upstream signaling for cerulein-induced IL-8 expression in pancreatic acinar cells.
Full Text
http://onlinelibrary.wiley.com/doi/10.1196/annals.1378.040/abstract
DOI
10.1196/annals.1378.040
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Hwan(김경환)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/110645
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