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Role of Mitogen-Activated Protein Kinases, NF-κB, and AP-1 on Cerulein-Induced IL-8 Expression in Pancreatic Acinar Cells

DC FieldValueLanguage
dc.contributor.author김경환-
dc.date.accessioned2015-06-10T12:53:51Z-
dc.date.available2015-06-10T12:53:51Z-
dc.date.issued2006-
dc.identifier.issn0077-8923-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/110645-
dc.description.abstractThe cholecystokine (CCK) analogue cerulein causes pathophysiological, morphological, and biochemical events similar to various aspects of human pancreatitis. Doses of CCK or cerulein beyond those that cause the maximum pancreatic secretion of amylase and lipase result in pancreatitis, which is characterized by a dysregulation of the digestive enzyme production and cytoplasmic vacuolization and the death of acinar cells, edema formation, and an infiltration of inflammatory cells into the pancreas. This study aims to investigate whether cerulein induces IL-8 expression in pancreatic acinar cells, and whether cerulein-induced IL-8 expression is inhibited in the cells transfected with mutant genes for c-jun (TAM-67), or IκBα (MAD-3) or treated inhibitors of mitogen-activated protein kinases (MAPKs). As a result, cerulein induced IL-expression, which was inhibited in the cells transfected with TAM-67 or MAD-3 or treated inhibitors of MAPK. In conclusion, activation of MAPK, nuclear factor-κB (NF-κB), and activator protein-1 (AP-1) may be the upstream signaling for cerulein-induced IL-8 expression in pancreatic acinar cells.-
dc.description.statementOfResponsibilityopen-
dc.format.extent368~374-
dc.relation.isPartOfANNALS OF THE NEW YORK ACADEMY OF SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHBase Sequence-
dc.subject.MESHCell Line-
dc.subject.MESHCeruletide/pharmacology*-
dc.subject.MESHDNA Primers-
dc.subject.MESHInterleukin-8/metabolism*-
dc.subject.MESHMitogen-Activated Protein Kinases/antagonists & inhibitors-
dc.subject.MESHMitogen-Activated Protein Kinases/metabolism*-
dc.subject.MESHNF-kappa B/metabolism*-
dc.subject.MESHPancreas/cytology-
dc.subject.MESHPancreas/drug effects*-
dc.subject.MESHPancreas/enzymology-
dc.subject.MESHPancreas/metabolism-
dc.subject.MESHProtein Kinase Inhibitors/pharmacology-
dc.subject.MESHRats-
dc.subject.MESHReverse Transcriptase Polymerase Chain Reaction-
dc.subject.MESHTranscription Factor AP-1/metabolism*-
dc.titleRole of Mitogen-Activated Protein Kinases, NF-κB, and AP-1 on Cerulein-Induced IL-8 Expression in Pancreatic Acinar Cells-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pharmacology (약리학)-
dc.contributor.googleauthorKYUNG DON JU-
dc.contributor.googleauthorJI HOON YU-
dc.contributor.googleauthorHYEYOUNG KIM-
dc.contributor.googleauthorKYUNG HWAN KIM-
dc.identifier.doi10.1196/annals.1378.040-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00311-
dc.relation.journalcodeJ00181-
dc.identifier.eissn1749-6632-
dc.identifier.pmid17384281-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1196/annals.1378.040/abstract-
dc.subject.keywordcerulein-
dc.subject.keywordIL‐8-
dc.subject.keywordAR42J cells-
dc.subject.keywordmitogen‐activated protein kinases-
dc.subject.keywordNF‐κB-
dc.subject.keywordAP‐1-
dc.contributor.alternativeNameKim, Kyung Hwan-
dc.contributor.affiliatedAuthorKim, Kyung Hwan-
dc.rights.accessRightsnot free-
dc.citation.volume1090-
dc.citation.startPage368-
dc.citation.endPage374-
dc.identifier.bibliographicCitationANNALS OF THE NEW YORK ACADEMY OF SCIENCES, Vol.1090 : 368-374, 2006-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers

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