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Mitomycin C inhibits recurrent avellino dystrophy after phototherapeutic keratectomy

Authors
 Tae-im Kim  ;  Jhang Ho Pak  ;  Ju-byung Chae  ;  Eung Kweon Kim  ;  Hungwon Tchah 
Citation
 CORNEA, Vol.25(2) : 220-223, 2006 
Journal Title
 CORNEA 
ISSN
 0277-3740 
Issue Date
2006
MeSH
Adult ; Corneal Dystrophies, Hereditary/drug therapy ; Corneal Dystrophies, Hereditary/pathology ; Corneal Dystrophies, Hereditary/surgery* ; Female ; Follow-Up Studies ; Humans ; Intraoperative Period ; Lasers, Excimer ; Male ; Middle Aged ; Mitomycin/administration & dosage* ; Mitomycin/therapeutic use ; Nucleic Acid Synthesis Inhibitors/administration & dosage* ; Nucleic Acid Synthesis Inhibitors/therapeutic use ; Ophthalmic Solutions ; Photorefractive Keratectomy* ; Secondary Prevention ; Visual Acuity
Keywords
Avellino corneal dystrophy ; mitomycin C ; photo-therapeutic keratectomy
Abstract
PURPOSE: To report 4 patients with Avellino corneal dystrophy (ACD) who were treated with 0.02% mitomycin C (MMC) during phototherapeutic keratectomy (PTK). METHODS: ACD was confirmed by polymorphism of the exon region in the BIGH3 gene using polymerase chain reaction followed by DNA sequencing analysis. Three patients with recurrent ACD and 1 patient with primary ACD underwent PTK. Intraoperative 0.02% MMC was applied topically with a soaked microsponge. RESULTS: There was no recurrence of ACD in the heterozygotes, but there were recurrences with best-corrected visual acuity of 20/30 in the 2 homozygotes. CONCLUSION: Intraoperative use of topical 0.02% MMC in conjunction with PTK may prevent or delay the recurrence of ACD for at least for 1 year.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00003226-200602000-00020&LSLINK=80&D=ovft
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eung Kweon(김응권) ORCID logo https://orcid.org/0000-0002-1453-8042
Kim, Tae Im(김태임) ORCID logo https://orcid.org/0000-0001-6414-3842
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/110496
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