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Predictive value of p53 and PCNA expression for occult neck metastases in patients with clinically node-negative oral tongue cancer

 Ki Chang Keum  ;  Eun Ji Chung  ;  Woong Sub Koom  ;  Jae Ho Cho  ;  Sang Ho Cho  ;  Eun Chang Choi  ;  Chang Geol Lee  ;  Chang Ok Suh  ;  Gwi Eon Kim 
 OTOLARYNGOLOGY-HEAD AND NECK SURGERY, Vol.135(6) : 858-864, 2006 
Journal Title
Issue Date
Female ; Head and Neck Neoplasms/metabolism* ; Head and Neck Neoplasms/secondary ; Humans ; Immunohistochemistry ; Lymphatic Metastasis/diagnosis* ; Male ; Middle Aged ; Neck Dissection ; Prognosis ; Proliferating Cell Nuclear Antigen/metabolism* ; Tongue Neoplasms/metabolism* ; Tongue Neoplasms/pathology ; Tumor Suppressor Protein p53/metabolism*
OBJECTIVE: In an attempt to identify molecular markers predictive of occult neck metastases, we investigated whether positive p53 or proliferating cell nuclear antigen (PCNA) immunoreactivities on deparaffinized sections of the primary tumor are correlated to the presence of occult neck node metastases in oral tongue cancer patients with clinically negative cervical nodes (N0). STUDY DESIGN AND SETTING: Between 1986 and 1997, 37 clinically N0 patients who underwent neck dissection (25 male, 12 female; mean age 54 years) were selected for p53 and PCNA staining. RESULTS: p53 and PCNA immunoreactivities were detected in 68% and 32%, respectively. There was no correlation between p53 or PCNA and other clinicopathological factors, such as tumor differentiation, tumor type, tumor size, and T-stage. Although tumor differentiation (P = 0.03) and tumor size (P = 0.03) were significantly correlated with occult neck metastases of oral tongue cancer by univariate analysis, no correlation was found between p53 or PCNA and the presence of occult neck metastasis. CONCLUSION: p53 and/or PCNA expression are unsuitable as biological markers predictive of lymph node metastases of oral tongue cancer. SIGNIFICANCE: p53- or PCNA-positive status are not a reliable parameter for selection of elective neck dissection in the management of N0 oral tongue cancer patients.
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1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Keum, Ki Chang(금기창) ORCID logo https://orcid.org/0000-0003-4123-7998
Koom, Woong Sub(금웅섭) ORCID logo https://orcid.org/0000-0002-9435-7750
Kim, Gwi Eon(김귀언)
Suh, Chang Ok(서창옥)
Lee, Chang Geol(이창걸) ORCID logo https://orcid.org/0000-0002-8702-881X
Cho, Sang Ho(조상호)
Cho, Jae Ho(조재호) ORCID logo https://orcid.org/0000-0001-9966-5157
Choi, Eun Chang(최은창)
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