Cited 15 times in
Predictive value of p53 and PCNA expression for occult neck metastases in patients with clinically node-negative oral tongue cancer
DC Field | Value | Language |
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dc.contributor.author | 금기창 | - |
dc.contributor.author | 금웅섭 | - |
dc.contributor.author | 김귀언 | - |
dc.contributor.author | 서창옥 | - |
dc.contributor.author | 이창걸 | - |
dc.contributor.author | 조상호 | - |
dc.contributor.author | 조재호 | - |
dc.contributor.author | 최은창 | - |
dc.date.accessioned | 2015-06-10T12:44:01Z | - |
dc.date.available | 2015-06-10T12:44:01Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0194-5998 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/110349 | - |
dc.description.abstract | OBJECTIVE: In an attempt to identify molecular markers predictive of occult neck metastases, we investigated whether positive p53 or proliferating cell nuclear antigen (PCNA) immunoreactivities on deparaffinized sections of the primary tumor are correlated to the presence of occult neck node metastases in oral tongue cancer patients with clinically negative cervical nodes (N0). STUDY DESIGN AND SETTING: Between 1986 and 1997, 37 clinically N0 patients who underwent neck dissection (25 male, 12 female; mean age 54 years) were selected for p53 and PCNA staining. RESULTS: p53 and PCNA immunoreactivities were detected in 68% and 32%, respectively. There was no correlation between p53 or PCNA and other clinicopathological factors, such as tumor differentiation, tumor type, tumor size, and T-stage. Although tumor differentiation (P = 0.03) and tumor size (P = 0.03) were significantly correlated with occult neck metastases of oral tongue cancer by univariate analysis, no correlation was found between p53 or PCNA and the presence of occult neck metastasis. CONCLUSION: p53 and/or PCNA expression are unsuitable as biological markers predictive of lymph node metastases of oral tongue cancer. SIGNIFICANCE: p53- or PCNA-positive status are not a reliable parameter for selection of elective neck dissection in the management of N0 oral tongue cancer patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 858~864 | - |
dc.relation.isPartOf | OTOLARYNGOLOGY-HEAD AND NECK SURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Head and Neck Neoplasms/metabolism* | - |
dc.subject.MESH | Head and Neck Neoplasms/secondary | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Lymphatic Metastasis/diagnosis* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neck Dissection | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Proliferating Cell Nuclear Antigen/metabolism* | - |
dc.subject.MESH | Tongue Neoplasms/metabolism* | - |
dc.subject.MESH | Tongue Neoplasms/pathology | - |
dc.subject.MESH | Tumor Suppressor Protein p53/metabolism* | - |
dc.title | Predictive value of p53 and PCNA expression for occult neck metastases in patients with clinically node-negative oral tongue cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Otorhinolaryngology (이비인후과학) | - |
dc.contributor.googleauthor | Ki Chang Keum | - |
dc.contributor.googleauthor | Eun Ji Chung | - |
dc.contributor.googleauthor | Woong Sub Koom | - |
dc.contributor.googleauthor | Jae Ho Cho | - |
dc.contributor.googleauthor | Sang Ho Cho | - |
dc.contributor.googleauthor | Eun Chang Choi | - |
dc.contributor.googleauthor | Chang Geol Lee | - |
dc.contributor.googleauthor | Chang Ok Suh | - |
dc.contributor.googleauthor | Gwi Eon Kim | - |
dc.identifier.doi | 10.1016/j.otohns.2006.02.011 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03825 | - |
dc.contributor.localId | A03901 | - |
dc.contributor.localId | A00272 | - |
dc.contributor.localId | A00273 | - |
dc.contributor.localId | A00321 | - |
dc.contributor.localId | A01919 | - |
dc.contributor.localId | A03240 | - |
dc.contributor.localId | A04161 | - |
dc.relation.journalcode | J02453 | - |
dc.identifier.eissn | 1097-6817 | - |
dc.identifier.pmid | 17141074 | - |
dc.identifier.url | http://oto.sagepub.com/content/135/6/858.long | - |
dc.contributor.alternativeName | Keum, Ki Chang | - |
dc.contributor.alternativeName | Koom, Woong Sub | - |
dc.contributor.alternativeName | Kim, Gwi Eon | - |
dc.contributor.alternativeName | Suh, Chang Ok | - |
dc.contributor.alternativeName | Lee, Chang Geol | - |
dc.contributor.alternativeName | Cho, Sang Ho | - |
dc.contributor.alternativeName | Cho, Jae Ho | - |
dc.contributor.alternativeName | Choi, Eun Chang | - |
dc.contributor.affiliatedAuthor | Cho, Sang Ho | - |
dc.contributor.affiliatedAuthor | Cho, Jae Ho | - |
dc.contributor.affiliatedAuthor | Keum, Ki Chang | - |
dc.contributor.affiliatedAuthor | Koom, Woong Sub | - |
dc.contributor.affiliatedAuthor | Kim, Gwi Eon | - |
dc.contributor.affiliatedAuthor | Suh, Chang Ok | - |
dc.contributor.affiliatedAuthor | Lee, Chang Geol | - |
dc.contributor.affiliatedAuthor | Choi, Eun Chang | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 135 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 858 | - |
dc.citation.endPage | 864 | - |
dc.identifier.bibliographicCitation | OTOLARYNGOLOGY-HEAD AND NECK SURGERY, Vol.135(6) : 858-864, 2006 | - |
dc.identifier.rimsid | 38729 | - |
dc.type.rims | ART | - |
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