5 241

Cited 39 times in

Effects of Topical Antiglaucoma Application on Conjunctival Impression Cytology Specimens

Authors
 Samin Hong  ;  Christopher Seungkyu Lee  ;  Kyoung Yul Seo  ;  Gong Je Seong  ;  Young Jae Hong 
Citation
 AMERICAN JOURNAL OF OPHTHALMOLOGY, Vol.142(1) : 185-186, 2006 
Journal Title
 AMERICAN JOURNAL OF OPHTHALMOLOGY 
ISSN
 0002-9394 
Issue Date
2006
MeSH
Administration, Topical ; Antihypertensive Agents/administration & dosage* ; Conjunctiva/drug effects* ; Conjunctiva/pathology* ; Cross-Sectional Studies ; Drug Therapy, Combination ; Epithelium/drug effects ; Epithelium/parasitology ; Glaucoma, Open-Angle/drug therapy* ; Humans ; Latanoprost ; Metaplasia ; Prostaglandins F, Synthetic/administration & dosage ; Sulfonamides/administration & dosage ; Thiophenes/administration & dosage ; Timolol/administration & dosage
Abstract
PURPOSE: To evaluate the changes in conjunctival impression cytology specimens from patients receiving various topical antiglaucoma medications. DESIGN: Cross-sectional comparative study. METHODS: Impression cytology specimens were obtained from the eyes taking no topical medication (n = 20) and from the eyes taking various antiglaucoma medications (timolol n = 34; latanoprost n = 40; dorzolamide n = 32; timolol + latanoprost n = 30; timolol + dorzolamide n = 34). Specimens were graded on a scale of zero to three according to Nelson's method. RESULTS: Cytology scores were significantly higher in the medication group than the control group. Mean cytology scores of the control, timolol, latanoprost, dorzolamide, timolol + latanoprost, and timolol + dorzolamide group were 0.20, 1.62, 2.00, 1.75, 2.13, and 2.44, respectively. Among the medication groups, cytology scores were significantly lower in the monotherapy group than the fixed-combination therapy group. CONCLUSIONS: Various topical antiglaucoma medications induce a significant degree of squamous metaplasia. Conjunctival surface could be altered after the long-term use of antiglaucoma medication.
Full Text
http://www.sciencedirect.com/science/article/pii/S0002939406003515
DOI
10.1016/j.ajo.2006.02.056
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Seo, Kyoung Yul(서경률) ORCID logo https://orcid.org/0000-0002-9855-1980
Seong, Gong Je(성공제) ORCID logo https://orcid.org/0000-0002-5456-4296
Lee, Christopher Seungkyu(이승규) ORCID logo https://orcid.org/0000-0001-5054-9470
Hong, Sa Min(홍사민)
Hong, Young Jae(홍영재)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/110175
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse