Lack of toll-like receptor 4 and 2 polymorphisms in Korean patients with bacteremia

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Authors: Hee Jung Yoon ; Jun Yong Choi ; Chang Oh Kim ; Yoon Seon Park ; Myoung Soo Kim ; Young Keun Kim ; So Youn Shin ; June Myung Kim ; Young Goo Song

MeSH: Bacteremia/blood ; Bacteremia/epidemiology* ; Bacteremia/genetics* ; Biomarkers/blood ; DNA Mutational Analysis ; Female ; Genetic Predisposition to Disease/epidemiology ; Genetic Predisposition to Disease/genetics ; Genetic Testing/methods ; Humans ; Korea/epidemiology ; Male ; Middle Aged ; Polymorphism, Single Nucleotide/genetics ; Prevalence ; Risk Assessment/methods* ; Risk Factors ; Toll-Like Receptor 2/blood ; Toll-Like Receptor 2/genetics* ; Toll-Like Receptor 4/blood ; Toll-Like Receptor 4/genetics*

Abstract: Toll-like receptors (TLRs) are pattern-recognition receptors that are important in innate immune responses to bacterial infection. The purpose of this study is to describe the prevalence of TLRs genetic variations in the bacteremic patients in Korea. A total of 154 patients with bacteremia and 179 healthy volunteers were included. The Asp299Gly and Thr399Ile allele of the TLR4 gene and Arg753Gln and Arg677Trp allele of the TLR2 gene were tested by PCR-RFLP. The DNA sequences were determined to confirm the PCR-RFLP results. Contrary to the expectation, no genetic polymorphisms were detected in both groups of this study, suggesting that it is very rare in Korean.