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Comparison of efficacy of cefoperazone/sulbactam and imipenem/cilastatin for treatment of acinetobacter bacteremia

 Jun Yong Choi  ;  Chang Oh Kim  ;  Yoon Seon Park  ;  Hee Jung Yoon  ;  So Youn Shin  ;  Young Keun Kim  ;  Myung Soo Kim  ;  Yeon-a Kim  ;  Young Goo Song  ;  Dongeun Yong  ;  Kyungwon Lee  ;  June Myung Kim 
 Yonsei Medical Journal, Vol.47(1) : 63-69, 2006 
Journal Title
 Yonsei Medical Journal 
Issue Date
Acinetobacter/drug effects ; Acinetobacter/isolation & purification ; Acinetobacter Infections/drug therapy* ; Acinetobacter Infections/mortality ; Adolescent ; Adult ; Aged ; Anti-Bacterial Agents/therapeutic use* ; Bacteremia/drug therapy* ; Cefoperazone/therapeutic use* ; Cilastatin/therapeutic use ; Drug Resistance, Bacterial ; Drug Therapy, Combination ; Female ; Humans ; Imipenem/therapeutic use ; Male ; Middle Aged ; Protease Inhibitors/therapeutic use ; Sulbactam/therapeutic use*
Acinetobacter ; bacteremia ; cefoperazone/sulbactam ; imipenem/cilastatin
Multiple antibiotic reisistance threatens successful treatment of Acinetobacter baumannii infections worldwide. Increasing interest in the well-known activity of sulbactam against the genus Acinetobacter has been aroused. The purpose of this study was to compare the outcomes for patients with Acinetobacter bacteremia treated with cefoperazone/sulbactam versus imipenem/cilastatin. Forty-seven patients with Acinetobacter baumannii bacteremia were analyzed through a retrospective review of their medical records for antibiotic therapy and clinical outcome. Thirty-five patients were treated with cefoperazone/sulbactam, and twelve patients with imipenem/cilastatin. The percentage of favorable response after 72 hours was not statistically different between cefoperazone/ sulbactam group and imipenem/ cilastatin group. The mortality rate was not statistically different, too. Cefoperazone/sulbactam was found to be as useful as imipenem/cilastatin for treating patients with Acinetobacter bacteremia.
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1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myoung Soo(김명수)
Kim, Yeon A(김연아)
Kim, June Myung(김준명)
Kim, Chang Oh(김창오) ORCID logo https://orcid.org/0000-0002-0773-5443
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Shin, So Youn(신소연)
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Yoon, Hee Jung(윤희정)
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
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