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Haplotype combination of Calpain-10 gene polymorphism is associated with metabolic syndrome in type 2 diabetes

Authors
 Eun Seok Kang  ;  Moonsuk Nam  ;  Hye Joo Kim  ;  Hyeong Jin Kim  ;  Sung Min Myoung  ;  Yumie Rhee  ;  Chul Woo Ahn  ;  Bong Soo Cha  ;  Hyun Chul Lee 
Citation
 DIABETES RESEARCH AND CLINICAL PRACTICE, Vol.73(3) : 268-275, 2006 
Journal Title
 DIABETES RESEARCH AND CLINICAL PRACTICE 
ISSN
 0168-8227 
Issue Date
2006
MeSH
Adult ; Blood Glucose/analysis ; Blood Pressure/physiology ; Calpain/genetics* ; Cholesterol, HDL/blood ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/genetics* ; Diabetes Mellitus, Type 2/physiopathology ; Female ; Gene Frequency ; Genetic Predisposition to Disease/genetics ; Genotype ; Glycated Hemoglobin A/metabolism ; Haplotypes/genetics* ; Humans ; Korea ; Male ; Middle Aged ; Odds Ratio ; Polymorphism, Single Nucleotide/genetics* ; Triglycerides/blood
Keywords
Calpain-10 ; Polymorphism ; Haplotype ; Metabolic syndrome
Abstract
Patients with metabolic syndrome are at increased risk of developing cardiovascular disease. The combinations of the haplotype created by the alleles of three single nucleotide polymorphisms (SNPs): SNP-43, -19, and -63 of the Calpain-10 gene (CAPN10), have been reported to be associated with the risk of type 2 diabetes in many populations. The aim of this study was to examine the association of the CAPN10 polymorphism with metabolic syndrome in patients with type 2 diabetes in Korea. Overall, 382 patients with type 2 diabetes were enrolled in this study. All the subjects were genotyped according to CAPN10 SNP-43, -19, and -63. The restriction fragment length polymorphism method was used for the three SNPs. The baseline presence of components of metabolic syndrome was determined. Two hundred and sixty-five (69.4%) patients had metabolic syndrome. Patients with the 111/121 haplotype combination showed a higher risk of hypertension than the other haplotype combinations (odd ratio (OR) = 2.334, P = 0.010). Patients with the 111/121 haplotype combination had a significantly high risk of metabolic syndrome (OR = 1.927, P = 0.042). The results of this study suggest that a novel 111/121 haplotype combination created by the CAPN10 SNP-43, -19, and -63 increases the susceptibility to the metabolic syndrome in patients with type 2 diabetes.
Full Text
http://www.sciencedirect.com/science/article/pii/S0168822706000386
DOI
10.1016/j.diabres.2006.01.011
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Institute of Gastroenterology (소화기병연구소) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Myoung, Sung Min(명성민)
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
Lee, Hyun Chul(이현철)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109783
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