Cited 19 times in
Haplotype combination of Calpain-10 gene polymorphism is associated with metabolic syndrome in type 2 diabetes
DC Field | Value | Language |
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dc.contributor.author | 강은석 | - |
dc.contributor.author | 명성민 | - |
dc.contributor.author | 안철우 | - |
dc.contributor.author | 이유미 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 차봉수 | - |
dc.date.accessioned | 2015-06-10T12:25:43Z | - |
dc.date.available | 2015-06-10T12:25:43Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0168-8227 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109783 | - |
dc.description.abstract | Patients with metabolic syndrome are at increased risk of developing cardiovascular disease. The combinations of the haplotype created by the alleles of three single nucleotide polymorphisms (SNPs): SNP-43, -19, and -63 of the Calpain-10 gene (CAPN10), have been reported to be associated with the risk of type 2 diabetes in many populations. The aim of this study was to examine the association of the CAPN10 polymorphism with metabolic syndrome in patients with type 2 diabetes in Korea. Overall, 382 patients with type 2 diabetes were enrolled in this study. All the subjects were genotyped according to CAPN10 SNP-43, -19, and -63. The restriction fragment length polymorphism method was used for the three SNPs. The baseline presence of components of metabolic syndrome was determined. Two hundred and sixty-five (69.4%) patients had metabolic syndrome. Patients with the 111/121 haplotype combination showed a higher risk of hypertension than the other haplotype combinations (odd ratio (OR) = 2.334, P = 0.010). Patients with the 111/121 haplotype combination had a significantly high risk of metabolic syndrome (OR = 1.927, P = 0.042). The results of this study suggest that a novel 111/121 haplotype combination created by the CAPN10 SNP-43, -19, and -63 increases the susceptibility to the metabolic syndrome in patients with type 2 diabetes. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 268~275 | - |
dc.relation.isPartOf | DIABETES RESEARCH AND CLINICAL PRACTICE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Blood Glucose/analysis | - |
dc.subject.MESH | Blood Pressure/physiology | - |
dc.subject.MESH | Calpain/genetics* | - |
dc.subject.MESH | Cholesterol, HDL/blood | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/blood | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/genetics* | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/physiopathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Frequency | - |
dc.subject.MESH | Genetic Predisposition to Disease/genetics | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Glycated Hemoglobin A/metabolism | - |
dc.subject.MESH | Haplotypes/genetics* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Odds Ratio | - |
dc.subject.MESH | Polymorphism, Single Nucleotide/genetics* | - |
dc.subject.MESH | Triglycerides/blood | - |
dc.title | Haplotype combination of Calpain-10 gene polymorphism is associated with metabolic syndrome in type 2 diabetes | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Eun Seok Kang | - |
dc.contributor.googleauthor | Moonsuk Nam | - |
dc.contributor.googleauthor | Hye Joo Kim | - |
dc.contributor.googleauthor | Hyeong Jin Kim | - |
dc.contributor.googleauthor | Sung Min Myoung | - |
dc.contributor.googleauthor | Yumie Rhee | - |
dc.contributor.googleauthor | Chul Woo Ahn | - |
dc.contributor.googleauthor | Bong Soo Cha | - |
dc.contributor.googleauthor | Hyun Chul Lee | - |
dc.identifier.doi | 10.1016/j.diabres.2006.01.011 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00068 | - |
dc.contributor.localId | A01350 | - |
dc.contributor.localId | A02270 | - |
dc.contributor.localId | A03012 | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A03996 | - |
dc.relation.journalcode | J00723 | - |
dc.identifier.eissn | 1872-8227 | - |
dc.identifier.pmid | 16546286 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0168822706000386 | - |
dc.subject.keyword | Calpain-10 | - |
dc.subject.keyword | Polymorphism | - |
dc.subject.keyword | Haplotype | - |
dc.subject.keyword | Metabolic syndrome | - |
dc.contributor.alternativeName | Kang, Eun Seok | - |
dc.contributor.alternativeName | Myung, Sung Min | - |
dc.contributor.alternativeName | Ahn, Chul Woo | - |
dc.contributor.alternativeName | Rhee, Yumie | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Kang, Eun Seok | - |
dc.contributor.affiliatedAuthor | Myung, Sung Min | - |
dc.contributor.affiliatedAuthor | Ahn, Chul Woo | - |
dc.contributor.affiliatedAuthor | Rhee, Yumie | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Cha, Bong Soo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 73 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 268 | - |
dc.citation.endPage | 275 | - |
dc.identifier.bibliographicCitation | DIABETES RESEARCH AND CLINICAL PRACTICE, Vol.73(3) : 268-275, 2006 | - |
dc.identifier.rimsid | 53418 | - |
dc.type.rims | ART | - |
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