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파킨슨병과 다계통위축증 감별 진단에 정량적 18-fluorodeoxyglucose PET의 유용성

Other Titles
 The Quantitative 18-fluorodeoxyglucose PET Study in the Differential Diagnosis between Idiopathic Parkinson's Disease and Multiple System Atrophy 
 류철형  ;  이승엽  ;  유영훈  ;  이명식 
 Journal of the Korean Neurological Association, Vol.24(1) : 31-37, 2006 
Journal Title
Journal of the Korean Neurological Association
Issue Date
Parkinson disease ; Multiple system atrophy ; Positron-Emission Tomography ; Fluorodeoxyglucose F18 ; Corpus striatum ; Cerebellum
Background: Overlapping clinical features of idiopathic Parkinson's disease (IPD) and multiple system atrophy (MSA) make it difficult to conduct an accurate differential diagnosis. We performed a quantitative F18- fluorodeoxyglucose PET (FDG PET) and measured the striatal and cerebellar glucose metabolism to evaluate the efficacy of a FDG PET study in the differential diagnosis between IPD and MSA.
Methods: This study included 19 patients with IPD, 28 patients with MSA (MSA-P:MSA-C=19:9) and 12 age matched normal controls. A FDG PET study was performed in all subjects and the original PET image was corrected with the radioactivity curve obtained by repetitive sampling of the radial arterial blood.
Results: The measurements of striatal and cerebellar glucose metabolisms of the patients with MSA-P were significantly lower than those of the patients with IPD (P<0.001). However, the measurement of the caudate nucleus provided the most reliable clue for the differential diagnosis between IPD and MSA-P (sensitivity 94.7% and specificity 94.7%). In the patients with MSA-C, the glucose metabolism of the cerebellar vermis (P<0.001), cerebellar cortex (P<0.001) and putamen (P<0.05) was significantly lower than those of the patients with IPD.
Conclusions: Quantitative FDG PET is a useful and reliable method in making a differential diagnosis between IPD and MSA.
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1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Lee, Myung Sik(이명식) ORCID logo https://orcid.org/0000-0002-8413-1854
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