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파킨슨병과 다계통위축증 감별 진단에 정량적 18-fluorodeoxyglucose PET의 유용성
DC Field | Value | Language |
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dc.contributor.author | 유영훈 | - |
dc.contributor.author | 이명식 | - |
dc.date.accessioned | 2015-06-10T12:24:44Z | - |
dc.date.available | 2015-06-10T12:24:44Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1225-7044 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109754 | - |
dc.description.abstract | Background: Overlapping clinical features of idiopathic Parkinson's disease (IPD) and multiple system atrophy (MSA) make it difficult to conduct an accurate differential diagnosis. We performed a quantitative F18- fluorodeoxyglucose PET (FDG PET) and measured the striatal and cerebellar glucose metabolism to evaluate the efficacy of a FDG PET study in the differential diagnosis between IPD and MSA. Methods: This study included 19 patients with IPD, 28 patients with MSA (MSA-P:MSA-C=19:9) and 12 age matched normal controls. A FDG PET study was performed in all subjects and the original PET image was corrected with the radioactivity curve obtained by repetitive sampling of the radial arterial blood. Results: The measurements of striatal and cerebellar glucose metabolisms of the patients with MSA-P were significantly lower than those of the patients with IPD (P<0.001). However, the measurement of the caudate nucleus provided the most reliable clue for the differential diagnosis between IPD and MSA-P (sensitivity 94.7% and specificity 94.7%). In the patients with MSA-C, the glucose metabolism of the cerebellar vermis (P<0.001), cerebellar cortex (P<0.001) and putamen (P<0.05) was significantly lower than those of the patients with IPD. Conclusions: Quantitative FDG PET is a useful and reliable method in making a differential diagnosis between IPD and MSA. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 31~37 | - |
dc.relation.isPartOf | Journal of the Korean Neurological Association | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 파킨슨병과 다계통위축증 감별 진단에 정량적 18-fluorodeoxyglucose PET의 유용성 | - |
dc.title.alternative | The Quantitative 18-fluorodeoxyglucose PET Study in the Differential Diagnosis between Idiopathic Parkinson's Disease and Multiple System Atrophy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Nuclear Medicine (핵의학) | - |
dc.contributor.googleauthor | 류철형 | - |
dc.contributor.googleauthor | 이승엽 | - |
dc.contributor.googleauthor | 유영훈 | - |
dc.contributor.googleauthor | 이명식 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02485 | - |
dc.contributor.localId | A02753 | - |
dc.relation.journalcode | J01835 | - |
dc.subject.keyword | Parkinson disease | - |
dc.subject.keyword | Multiple system atrophy | - |
dc.subject.keyword | Positron-Emission Tomography | - |
dc.subject.keyword | Fluorodeoxyglucose F18 | - |
dc.subject.keyword | Corpus striatum | - |
dc.subject.keyword | Cerebellum | - |
dc.contributor.alternativeName | Ryu, Young Hoon | - |
dc.contributor.alternativeName | Lee, Myung Sik | - |
dc.contributor.affiliatedAuthor | Ryu, Young Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Myung Sik | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 24 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 31 | - |
dc.citation.endPage | 37 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Neurological Association, Vol.24(1) : 31-37, 2006 | - |
dc.identifier.rimsid | 53397 | - |
dc.type.rims | ART | - |
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