Cited 6 times in
Expression of Ca2+-dependent Synaptotagmin Isoforms in Mouse and Rat Parotid Acinar Cells
DC Field | Value | Language |
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dc.contributor.author | 서정택 | - |
dc.contributor.author | 손흥규 | - |
dc.contributor.author | 신동민 | - |
dc.contributor.author | 이승일 | - |
dc.date.accessioned | 2015-06-10T12:11:01Z | - |
dc.date.available | 2015-06-10T12:11:01Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109339 | - |
dc.description.abstract | Synaptotagmin is a Ca2+ sensing protein, which triggers a fusion of synaptic vesicles in neuronal transmission. Little is known regarding the expression of Ca2+-dependent synaptotagmin isoforms and their contribution to the release of secretory vesicles in mouse and rat parotid acinar cells. We investigated a type of Ca2+-dependent synaptotagmin and Ca2+ signaling in both rat and mouse parotid acinar cells using RT-PCR, microfluorometry, and amylase assay. Mouse parotid acinar cells exhibited much more sensitive amylase release in response to muscarinic stimulation than did rat parotid acinar cells. However, transient [Ca2+]i increases and Ca2+ influx in response to muscarinic stimulation in both cells were identical, suggesting that the expression or activity of the Ca2+ sensing proteins is different. Seven Ca2+-dependent synaptotagmins, from 1 to 7, were expressed in the mouse parotid acinar cells. However, in the rat parotid acinar cells, only synaptotagmins 1, 3, 4 and 7 were expressed. These results indicate that the expression of Ca2+-dependent synaptotagmins may contribute to the release of secretory vesicles in parotid acinar cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 70~77 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Amylases/metabolism | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Calcium/metabolism | - |
dc.subject.MESH | Calcium/physiology* | - |
dc.subject.MESH | Carbachol/pharmacology | - |
dc.subject.MESH | Exocytosis/drug effects | - |
dc.subject.MESH | Exocytosis/physiology | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Muscarinic Agonists/pharmacology | - |
dc.subject.MESH | Parotid Gland/cytology | - |
dc.subject.MESH | Parotid Gland/metabolism* | - |
dc.subject.MESH | Protein Isoforms/metabolism | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Signal Transduction | - |
dc.subject.MESH | Synaptotagmins/metabolism* | - |
dc.title | Expression of Ca2+-dependent Synaptotagmin Isoforms in Mouse and Rat Parotid Acinar Cells | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학) | - |
dc.contributor.googleauthor | Hae Jo | - |
dc.contributor.googleauthor | Hae Mi Byun | - |
dc.contributor.googleauthor | Jong-hoon Kim | - |
dc.contributor.googleauthor | Min Seuk Kim | - |
dc.contributor.googleauthor | Seung-hyeoi Kim | - |
dc.contributor.googleauthor | Jeong Hee Hong | - |
dc.contributor.googleauthor | Jeong Taeg Seo | - |
dc.contributor.googleauthor | Syng-ill Lee | - |
dc.contributor.googleauthor | Dong Min Shin | - |
dc.contributor.googleauthor | Heung-kyu Son | - |
dc.identifier.doi | 10.3349/ymj.2006.47.1.70 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01905 | - |
dc.contributor.localId | A02005 | - |
dc.contributor.localId | A02091 | - |
dc.contributor.localId | A02924 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 16502487 | - |
dc.subject.keyword | Synaptotagmin | - |
dc.subject.keyword | calcium signaling | - |
dc.subject.keyword | exocytosis | - |
dc.subject.keyword | parotid acinar cells | - |
dc.contributor.alternativeName | Seo, Jeong Taeg | - |
dc.contributor.alternativeName | Son, Heung Kyu | - |
dc.contributor.alternativeName | Shin, Dong Min | - |
dc.contributor.alternativeName | Lee, Syng Ill | - |
dc.contributor.affiliatedAuthor | Seo, Jeong Taeg | - |
dc.contributor.affiliatedAuthor | Son, Heung Kyu | - |
dc.contributor.affiliatedAuthor | Shin, Dong Min | - |
dc.contributor.affiliatedAuthor | Lee, Syng Ill | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 47 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 70 | - |
dc.citation.endPage | 77 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.47(1) : 70-77, 2006 | - |
dc.identifier.rimsid | 52291 | - |
dc.type.rims | ART | - |
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