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Adiponectin protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity

Authors
 Tae Woo Jung  ;  Ji Young Lee  ;  Wan Sub Shim  ;  Eun Seok Kang  ;  Jong Sun Kim  ;  Chul Woo Ahn  ;  Hyun Chul Lee  ;  Bong Soo Cha 
Citation
 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.343(2) : 564-570, 2006 
Journal Title
 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 
ISSN
 0006-291X 
Issue Date
2006
MeSH
1-Methyl-4-phenylpyridinium/pharmacology* ; Adiponectin/pharmacology* ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; Drug Combinations ; Humans ; Neuroblastoma/metabolism* ; Neuroblastoma/pathology* ; Neuroprotective Agents/pharmacology ; Reactive Oxygen Species/metabolism*
Keywords
MPP+Parkinson’s diseaseAdiponectinROSSODCatalase
Abstract
1-Methyl-4-phenylpyridinium ion (MPP+), an inhibitor of mitochondrial complex I, has been widely used as a neurotoxin because it elicits a severe Parkinson’s disease-like syndrome characterized by elevation of intracellular reactive oxygen species level and apoptotic death. Adiponectin, secreted from adipose tissue, mediates systemic insulin sensitivity with liver and muscle as target organs. Adiponectin can also suppress superoxide generation in endothelial cells. In the present study, we investigated the protective effects of adiponectin on MPP+-induced cytotoxicity in human neuroblastoma SH-SY5Y cells, as well as the underlying mechanism. Our results suggest that the protective effects of adiponectin on MPP+-induced apoptosis may be ascribed to its anti-oxidative properties, anti-apoptotic activity via inducing expression of SOD and catalase, and regulation of Bcl-2 and Bax expression. These data indicated that adiponectin might provide a useful therapeutic strategy for the treatment of progressive neurodegenerative diseases such as Parkinson’s disease.
Full Text
http://www.sciencedirect.com/science/article/pii/S0006291X06004700
DOI
10.1016/j.bbrc.2006.02.186
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Kim, Jong Sun(김종선) ORCID logo https://orcid.org/0000-0002-3149-669X
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Hyun Chul(이현철)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109218
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