Cited 43 times in
Adiponectin protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity
DC Field | Value | Language |
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dc.contributor.author | 강은석 | - |
dc.contributor.author | 김종선 | - |
dc.contributor.author | 안철우 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 차봉수 | - |
dc.date.accessioned | 2015-06-10T12:06:59Z | - |
dc.date.available | 2015-06-10T12:06:59Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109218 | - |
dc.description.abstract | 1-Methyl-4-phenylpyridinium ion (MPP+), an inhibitor of mitochondrial complex I, has been widely used as a neurotoxin because it elicits a severe Parkinson’s disease-like syndrome characterized by elevation of intracellular reactive oxygen species level and apoptotic death. Adiponectin, secreted from adipose tissue, mediates systemic insulin sensitivity with liver and muscle as target organs. Adiponectin can also suppress superoxide generation in endothelial cells. In the present study, we investigated the protective effects of adiponectin on MPP+-induced cytotoxicity in human neuroblastoma SH-SY5Y cells, as well as the underlying mechanism. Our results suggest that the protective effects of adiponectin on MPP+-induced apoptosis may be ascribed to its anti-oxidative properties, anti-apoptotic activity via inducing expression of SOD and catalase, and regulation of Bcl-2 and Bax expression. These data indicated that adiponectin might provide a useful therapeutic strategy for the treatment of progressive neurodegenerative diseases such as Parkinson’s disease. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 564~570 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | 1-Methyl-4-phenylpyridinium/pharmacology* | - |
dc.subject.MESH | Adiponectin/pharmacology* | - |
dc.subject.MESH | Apoptosis/drug effects | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Survival/drug effects | - |
dc.subject.MESH | Drug Combinations | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Neuroblastoma/metabolism* | - |
dc.subject.MESH | Neuroblastoma/pathology* | - |
dc.subject.MESH | Neuroprotective Agents/pharmacology | - |
dc.subject.MESH | Reactive Oxygen Species/metabolism* | - |
dc.title | Adiponectin protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Tae Woo Jung | - |
dc.contributor.googleauthor | Ji Young Lee | - |
dc.contributor.googleauthor | Wan Sub Shim | - |
dc.contributor.googleauthor | Eun Seok Kang | - |
dc.contributor.googleauthor | Jong Sun Kim | - |
dc.contributor.googleauthor | Chul Woo Ahn | - |
dc.contributor.googleauthor | Hyun Chul Lee | - |
dc.contributor.googleauthor | Bong Soo Cha | - |
dc.identifier.doi | 10.1016/j.bbrc.2006.02.186 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00068 | - |
dc.contributor.localId | A00921 | - |
dc.contributor.localId | A02270 | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A03996 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.pmid | 16554029 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X06004700 | - |
dc.subject.keyword | MPP+Parkinson’s diseaseAdiponectinROSSODCatalase | - |
dc.contributor.alternativeName | Kang, Eun Seok | - |
dc.contributor.alternativeName | Kim, Jong Sun | - |
dc.contributor.alternativeName | Ahn, Chul Woo | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Kang, Eun Seok | - |
dc.contributor.affiliatedAuthor | Kim, Jong Sun | - |
dc.contributor.affiliatedAuthor | Ahn, Chul Woo | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Cha, Bong Soo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 343 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 564 | - |
dc.citation.endPage | 570 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.343(2) : 564-570, 2006 | - |
dc.identifier.rimsid | 55767 | - |
dc.type.rims | ART | - |
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