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Adiponectin protects human neuroblastoma SH-SY5Y cells against acetaldehyde-induced cytotoxicity

Authors
 Tae Woo Jung  ;  Ji Young Lee  ;  Wan Sub Shim  ;  Eun Seok Kang  ;  Jong Sun Kim  ;  Chul Woo Ahn  ;  Hyun Chul Lee  ;  Bong Soo Cha 
Citation
 BIOCHEMICAL PHARMACOLOGY, Vol.72(5) : 616-623, 2006 
Journal Title
 BIOCHEMICAL PHARMACOLOGY 
ISSN
 0006-2952 
Issue Date
2006
MeSH
Acetaldehyde/toxicity* ; Adiponectin/pharmacology* ; Apoptosis ; Caspase 3 ; Caspases/metabolism ; Cell Line, Tumor ; Cytochromes c/metabolism ; Humans ; Neuroblastoma/pathology* ; Oxidative Stress ; RNA, Messenger/genetics ; Reactive Oxygen Species/metabolism ; Receptors, Adiponectin ; Receptors, Cell Surface/metabolism
Keywords
Acetaldehyde ; Parkinson's disease ; Adiponectin ; ROSApoptosis ; SH-SY5Y
Abstract
Acetaldehyde, an inhibitor of mitochondrial function, has been widely used as a neurotoxin because it elicits a severe Parkinson's disease-like syndrome with elevation of the intracellular reactive oxygen species (ROS) level and apoptosis. Adiponectin, secreted from adipose tissue, mediates systemic insulin sensitivity with liver and muscle as target organs. In this study, we investigated the protective effects of adiponectin on acetaldehyde-induced apoptosis in human neuroblastoma SH-SY5Y cells and attempted to examine its mechanism. Acetaldehyde-induced apoptosis was moderately reversed by adiponectin treatment. Our results suggest that the protective effects of adiponectin on acetaldehyde-induced apoptosis may be ascribed to ability to induce the expression of anti-oxidant enzymes and to regulate Bcl-2 and Bax expression. These data indicate that adiponectin may provide a useful therapeutic strategy for the prevention of progressive neurodegenerative disease such as Parkinson's disease.
Full Text
http://www.sciencedirect.com/science/article/pii/S0006295206003145
DOI
10.1016/j.bcp.2006.05.013
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Kim, Jong Sun(김종선) ORCID logo https://orcid.org/0000-0002-3149-669X
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Hyun Chul(이현철)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109214
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