Cited 27 times in
Adiponectin protects human neuroblastoma SH-SY5Y cells against acetaldehyde-induced cytotoxicity
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강은석 | - |
dc.contributor.author | 김종선 | - |
dc.contributor.author | 안철우 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 차봉수 | - |
dc.date.accessioned | 2015-06-10T12:06:51Z | - |
dc.date.available | 2015-06-10T12:06:51Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0006-2952 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109214 | - |
dc.description.abstract | Acetaldehyde, an inhibitor of mitochondrial function, has been widely used as a neurotoxin because it elicits a severe Parkinson's disease-like syndrome with elevation of the intracellular reactive oxygen species (ROS) level and apoptosis. Adiponectin, secreted from adipose tissue, mediates systemic insulin sensitivity with liver and muscle as target organs. In this study, we investigated the protective effects of adiponectin on acetaldehyde-induced apoptosis in human neuroblastoma SH-SY5Y cells and attempted to examine its mechanism. Acetaldehyde-induced apoptosis was moderately reversed by adiponectin treatment. Our results suggest that the protective effects of adiponectin on acetaldehyde-induced apoptosis may be ascribed to ability to induce the expression of anti-oxidant enzymes and to regulate Bcl-2 and Bax expression. These data indicate that adiponectin may provide a useful therapeutic strategy for the prevention of progressive neurodegenerative disease such as Parkinson's disease. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 616~623 | - |
dc.relation.isPartOf | BIOCHEMICAL PHARMACOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acetaldehyde/toxicity* | - |
dc.subject.MESH | Adiponectin/pharmacology* | - |
dc.subject.MESH | Apoptosis | - |
dc.subject.MESH | Caspase 3 | - |
dc.subject.MESH | Caspases/metabolism | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cytochromes c/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Neuroblastoma/pathology* | - |
dc.subject.MESH | Oxidative Stress | - |
dc.subject.MESH | RNA, Messenger/genetics | - |
dc.subject.MESH | Reactive Oxygen Species/metabolism | - |
dc.subject.MESH | Receptors, Adiponectin | - |
dc.subject.MESH | Receptors, Cell Surface/metabolism | - |
dc.title | Adiponectin protects human neuroblastoma SH-SY5Y cells against acetaldehyde-induced cytotoxicity | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | Tae Woo Jung | - |
dc.contributor.googleauthor | Ji Young Lee | - |
dc.contributor.googleauthor | Wan Sub Shim | - |
dc.contributor.googleauthor | Eun Seok Kang | - |
dc.contributor.googleauthor | Jong Sun Kim | - |
dc.contributor.googleauthor | Chul Woo Ahn | - |
dc.contributor.googleauthor | Hyun Chul Lee | - |
dc.contributor.googleauthor | Bong Soo Cha | - |
dc.identifier.doi | 10.1016/j.bcp.2006.05.013 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00068 | - |
dc.contributor.localId | A00921 | - |
dc.contributor.localId | A02270 | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A03996 | - |
dc.relation.journalcode | J00283 | - |
dc.identifier.eissn | 1873-2968 | - |
dc.identifier.pmid | 16814256 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006295206003145 | - |
dc.subject.keyword | Acetaldehyde | - |
dc.subject.keyword | Parkinson's disease | - |
dc.subject.keyword | Adiponectin | - |
dc.subject.keyword | ROSApoptosis | - |
dc.subject.keyword | SH-SY5Y | - |
dc.contributor.alternativeName | Kang, Eun Seok | - |
dc.contributor.alternativeName | Kim, Jong Sun | - |
dc.contributor.alternativeName | Ahn, Chul Woo | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Kang, Eun Seok | - |
dc.contributor.affiliatedAuthor | Kim, Jong Sun | - |
dc.contributor.affiliatedAuthor | Ahn, Chul Woo | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Cha, Bong Soo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 72 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 616 | - |
dc.citation.endPage | 623 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL PHARMACOLOGY, Vol.72(5) : 616-623, 2006 | - |
dc.identifier.rimsid | 55763 | - |
dc.type.rims | ART | - |
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