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Hyperintense nodules on non-enhanced T1-weighted gradient-echo magnetic resonance imaging of cirrhotic liver: Fate and clinical implications

Authors
 Jeong-Sik Yu  ;  Jei Hee Lee  ;  Mi-Suk Park  ;  Ki Whang Kim 
Citation
 JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol.24(3) : 630-636, 2006 
Journal Title
 JOURNAL OF MAGNETIC RESONANCE IMAGING 
ISSN
 1053-1807 
Issue Date
2006
MeSH
Adult ; Aged ; Cell Transformation, Neoplastic ; Contrast Media/pharmacology ; Female ; Fibrosis/diagnosis* ; Fibrosis/pathology* ; Humans ; Liver/pathology* ; Liver Neoplasms/pathology ; Magnetic Resonance Imaging/methods* ; Male ; Middle Aged ; Retrospective Studies ; Time Factors ; Treatment Outcome
Keywords
liver, cirrhosis ; liver, nodules ; liver, neoplasms ; liver, neoplasms ; MR
Abstract
PURPOSE: To investigate the fate of hyperintense hepatic nodules on nonenhanced T1-weighted (T1w) gradient-echo (GRE) magnetic resonance (MR) images in cirrhotic patients. MATERIALS AND METHODS: A total of 79 cirrhotic patients with hyperintense nodules (>5 mm) on precontrast opposed-phase (repetition time (TR)/echo time (TE) = 140/2.7 msec) GRE images from initial MRI without T2-weighted (T2w) hyperintensity or arterial hypervascularity were subjected to analysis of subsequent MR images obtained at intervals of 12-56 months (mean = 24.5 months). Multiplicity of hyperintense nodules (group A, up to 8; group B, >8) was correlated with follow-up changes. RESULTS: Group B patients were younger (P = 0.003) than group A patients (mean = 47.5 and 56.2 years, respectively). In 66 group A patients, 39 out of 143 lesions (27%) were enlarged, including 20 malignantly transformed or borderline lesions. Of the 104 lesions (the eight largest lesions in each patient) in 13 group B patients, only three (2.9%) were enlarged. The results of best- and worst-case analyses showed that overall the lesions were benign in 91% and 82% of patients, respectively. CONCLUSION: T1w hyperintense nodules without T2w hyperintensity or arterial hypervascularity in the cirrhotic liver are benign in most cases. In younger patients with numerous macronodules, almost all of these lesions follow a benign course.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jmri.20674/abstract
DOI
10.1002/jmri.20674
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Whang(김기황)
Park, Mi-Suk(박미숙) ORCID logo https://orcid.org/0000-0001-5817-2444
Yu, Jeong Sik(유정식) ORCID logo https://orcid.org/0000-0002-8171-5838
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109051
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