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Nanomedical imaging: In vivo imaging with smart nanohybrid

Authors
 Yong-Min Huh  ;  Young Jin Kim 
Citation
 Current Applied Physics, Vol.6(Suppl1) : 22-25, 2006 
Journal Title
 Current Applied Physics 
ISSN
 1567-1739 
Issue Date
2006
Abstract
The unique optical, magnetic, and electronic properties of nanocrystals enable them to be key probes and vectors in the next generation of biomedical applications. Semiconductor quantum dots have been demonstrated as excellent fluorescent probes. However, they suffer from the intrinsic limitations of optical imaging systems such as low penetration depth and large background fluorescence. Magnetic nanocrystals are now emerging in biomedical applications with new possibilities. We have demonstrated the production of high quality water-soluble iron oxide (WSIO) nanocrystals by thermal decomposition method. One of the current challenges now is how to develop well-defined magnetic nanocrystals with optimal nanoscale magnetism, high bio-stability to withstand harsh biological conditions, Conjugation of biologically functional molecules to nanocrystals produce nanohybrids that have multi-functionality such as detection, diagnosis, and therapeutics. However, further development of in vivo imaging applications of these molecules has been very limited with very few successful in vivo demonstrations. In addition to therapeutic antibody, the ability to incorporate genes or drugs into detectable site-targeted nanosystems may represent a whole new paradigm in therapeutics. The application for molecular and cellar imaging in nanoscience have not been fully developed. However, it has enormous potential for development and nanocrystals will bring improvement in bio-medical sciences.
Full Text
http://www.sciencedirect.com/science/article/pii/S156717390600006X
DOI
10.1016/j.cap.2006.01.005
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109040
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