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Calcium uptake and release through sarcoplasmic reticulum in the inferior oblique muscles of patients with inferior oblique overaction

Authors
 Hee Seon Kim  ;  Yoon-hee Chang  ;  Do Han Kim  ;  So Ra Park  ;  Sueng-han Han  ;  Jong Bok Lee 
Citation
 YONSEI MEDICAL JOURNAL, Vol.47(2) : 207-213, 2006 
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
 0513-5796 
Issue Date
2006
MeSH
Adolescent ; Adult ; Aged ; Blotting, Western ; Calcium/metabolism ; Calcium/pharmacokinetics* ; Calcium-Transporting ATPases/metabolism ; Calsequestrin/metabolism ; Child ; Child, Preschool ; Female ; Humans ; Male ; Middle Aged ; Models, Statistical ; Muscles/pathology* ; Ocular Motility Disorders/metabolism* ; Ocular Motility Disorders/pathology* ; Oculomotor Muscles ; Oxalates/metabolism ; Ryanodine/metabolism ; Ryanodine Receptor Calcium Release Channel/metabolism ; Sarcoplasmic Reticulum/metabolism* ; Sarcoplasmic Reticulum Calcium-Transporting ATPases
Keywords
Calcium ; calsequestrin ; inferior oblique overaction ; ryanodine receptor ; sarcoplasmic reticulum ; sarcoplasmic reticulum Ca2+-ATPase 1
Abstract
We characterized and compared the characteristics of Ca2+ movements through the sarcoplasmic reticulum of inferior oblique muscles in the various conditions including primary inferior oblique overaction (IOOA), secondary IOOA, and controls, so as to further understand the pathogenesis of primary IOOA. Of 15 specimens obtained through inferior oblique myectomy, six were from primary IOOA, 6 from secondary IOOA, and the remaining 3 were controls from enucleated eyes. Ryanodine binding assays were performed, and Ca2+ uptake rates, calsequestrins and SERCA levels were determined. Ryanodine bindings and sarcoplasmic reticulum Ca2+ uptake rates were significantly decreased in primary IOOA (p<0.05). Western blot analysis conducted to quantify calsequestrins and SERCA, found no significant difference between primary IOOA, secondary IOOA, and the controls. Increased intracellular Ca2+ concentration due to reduced sarcoplasmic reticulum Ca2+ uptake may play a role in primary IOOA.
Files in This Item:
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DOI
10.3349/ymj.2006.47.2.207
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Jong Bok(이종복)
Han, Seung Han(한승한) ORCID logo https://orcid.org/0000-0001-8972-4790
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109015
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