1 339

Cited 79 times in

Effects of lifestyle modification on metabolic parameters and carotid intima-media thickness in patients with type 2 diabetes mellitus

Authors
 So Hun Kim  ;  Suk Jeong Lee  ;  Eun Seok Kang  ;  Shinae Kang  ;  Kyu Yeon Hur  ;  Hyun Joo Lee  ;  Chul Woo Ahn  ;  Bong Soo Cha  ;  Ji Soo Yoo  ;  Hyun Chul Lee 
Citation
 METABOLISM-CLINICAL AND EXPERIMENTAL, Vol.55(8) : 1053-1059, 2006 
Journal Title
 METABOLISM-CLINICAL AND EXPERIMENTAL 
ISSN
 0026-0495 
Issue Date
2006
MeSH
Aged ; Anthropometry ; Behavior Therapy ; Blood Glucose/metabolism ; Blood Pressure/physiology ; Body Weight/physiology ; Carotid Arteries/diagnostic imaging ; Carotid Arteries/pathology* ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/pathology* ; Diabetes Mellitus, Type 2/therapy* ; Diet ; Dyslipidemias/therapy ; Echocardiography ; Exercise ; Female ; Humans ; Hypoglycemic Agents/therapeutic use ; Life Style* ; Male ; Middle Aged ; Obesity/complications ; Obesity/therapy ; Patient Compliance ; Treatment Outcome
Abstract
The aim of this study was to examine the effects of a 6-month intensive lifestyle modification intervention on metabolic parameters and carotid intima-media thickness (IMT) in patients with type 2 diabetes mellitus. Fifty-eight subjects with type 2 diabetes mellitus were randomly assigned to the intervention group or the control group. The subjects in the intervention group participated in a 16-week intensive lifestyle modification program and subsequent monthly meetings during the 6-month study period. Control subjects received basic dietary education and usual care. Anthropometric data, metabolic parameters, and carotid IMT were examined before the intervention and after 6 months. Lifestyle modification intervention group patients showed a significant reduction in HbA1c (−1.0% ± 1.3% vs +0.1% ± 1.2%, P = .002), fasting blood glucose (−1.6 ± 1.5 vs +0.3 ± 2.5 mmol/L, P = .001), and 2-hour postprandial plasma glucose (−2.1 ± 2.5 vs +0.8 ± 4.4 mmol/L, P = .003) compared with control patients after 6 months. Body weight (−2.0 ± 2.6 vs +0.2 ± 1.7 kg, P = .001), body mass index (−0.8 ± 1.0 vs 0.0 ± 0.8 kg/m2, P = .003), and systolic blood pressure (−8.2 ± 15.9 vs +0.4 ± 14.1 mm Hg, P = .041) were significantly decreased in the intervention group. A significantly reduced carotid mean IMT progression was seen in the intervention group after 6 months (−0.040 ± 0.136 vs +0.083 ± 0.167 mm, P = .007). Changes in HbA1c (r = 0.34, P = .028), fasting plasma glucose (r = 0.31, P = .045), and 2-hour postprandial plasma glucose (r = 0.37, P = .015) correlated with the mean carotid IMT change after adjustment for age and sex. In conclusion, a 6-month intensive lifestyle modification intervention in patients with type 2 diabetes mellitus resulted in improved glycemic control and decreased progression of carotid IMT.
Full Text
http://www.sciencedirect.com/science/article/pii/S002604950600120X
DOI
10.1016/j.metabol.2006.03.017
Appears in Collections:
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Yoo, Ji Soo(유지수)
Lee, Hyun Chul(이현철)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/108902
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse