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노화와 운동이 백서의 항산화 유전자 발현에 미치는 영향

Other Titles
 Alteration of Antioxidant Enzyme Gene Expression with Aging and Exercise in Fisher Rats. 
 조봉준  ;  김준태  ;  이유진  ;  유성훈  ;  최성희  ;  임수  ;  임재영  ;  장혁재  ;  박영주  ;  장학철 
 Journal of the Korean Geriatrics Society (노인병), Vol.12(3) : 146-152, 2008 
Journal Title
 Journal of the Korean Geriatrics Society (노인병) 
Issue Date
Aging, Exercise ; Reactive Oxygen Species (ROS) ; Catalase ; Glutathione peroxidase
BACKGROUND: It has been reported that radical oxygen species(ROS) production increased drastically during ageing. This increase in ROS had negative effects on many age-related diseases. In this study, we investigated the effects of ageing and exercise on antioxidant gene expression in Fisher rats and the mechanism of chronic exercise on ROS generation related to ageing. METHODS: After a standard diet, young and old male Fischer rats were assigned to sedentary control groups(young control group: YC, old control group: OC) and exercise training groups(young exercised group: YE, old exercised group: OE). After a 12-week treadmill exercise training in the exercise training groups, antioxidant gene expre- ssion(catalase, glutathione peroxidase) in the liver and muscle was measured by RT-PCR(reverse transcription- polymerase chain reaction). RESULTS: Liver catalase mRNA expression was lower in the old group compared with that in the young group. However, this remained unchanged post-exercise. Liver glutathione peroxidase mRNA expression was not different between the young and old groups and remained unchanged in both these groups. The expression of catalase mRNA in the soleus muscle was significantly lower in the old control rats compared with that in the young rats. Exercise sig- nificantly increased catalase mRNA expression in the soleus in both the young and old rats. The expression of gluta- thione peroxidase mRNA in the soleus was lower in the old control rats than in the young. Exercise significantly increased glutathione peroxidase mRNA expression in both young and old rats. CONCLUSION: This study showed that chronic exercise could be an important contributor to the recovery in the decline of certain antioxidant gene expressions in both young and aged rats. Long-term exercise may posi- tively affect metabolic diseases by modulating antioxidant gene expression.
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1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Chang, Hyuk-Jae(장혁재) ORCID logo https://orcid.org/0000-0002-6139-7545
Cho, Bong Jun(조봉준)
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