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Pattern Visual Evoked Potential as a Predictor of Occlusion Therapy for Amblyopia

 Woosuk Chung  ;  Samin Hong  ;  Jong Bok Lee  ;  Sueng-Han Han 
 Korean Journal of Ophthalmology, Vol.22(4) : 251-254, 2008 
Journal Title
 Korean Journal of Ophthalmology 
Issue Date
Adolescent ; Amblyopia/physiopathology* ; Amblyopia/therapy* ; Anisometropia/physiopathology ; Anisometropia/therapy ; Child ; Child, Preschool ; Evoked Potentials, Visual/physiology* ; Female ; Humans ; Male ; Retrospective Studies ; Sensory Deprivation* ; Strabismus/physiopathology ; Strabismus/therapy ; Treatment Outcome ; Visual Acuity
Amblyopia ; P100 latency ; Visual evoked potential
PURPOSE: This study was conducted to investigate the role of the pattern visual evoked potential (pVEP) as a predictor of occlusion therapy for patients with strabismic, anisometropic, and isometropic amblyopia. The secondary aim was to compare the characteristics of pVEP between strabismic and anisometropic amblyopia. METHODS: This retrospective comparative case series included 120 patients who had received occlusion therapy or a glasses prescription for correction of strabismic, anisometropic, and isometropic amblyopia (20 patients had strabismic amblyopia, 41 patients had anisometropic amblyopia, and 59 patients had isometropic amblyopia). For each patient, the value of the P100 latency on pVEP at the time of the initial diagnosis of amblyopia was collected. Subsequently, the P100 latency was compared according to types of amblyopia. Fifty of 120 patients (7 patients with strabismic amblyopia, 21 patients with anisometropic amblyopia, and 22 patients with isometropic amblyopia) who were followed-up for longer than 6 months were divided into two groups based on the value of their P100 latency (Group 1, P100 latency 120 msec or less; Group 2, P100 latency longer than 120 msec.) The amount of visual improvement after occlusion therapy or glasses was compared between two study groups. RESULTS: The mean P100 latency was 119.7+/-25.2 msec in eyes with strabismic amblyopia and 111.9+/-17.8 msec in eyes with non-strabismic (anisometropic or isometropic) amblyopia (p=0.213). In Group 1, the mean visual improvement after occlusion therapy or glasses was 3.69+/-2.14 lines on Dr. Hahn's standard test chart; in Group 2, the mean improvement was 2.27+/-2.21 lines (p=0.023). CONCLUSIONS: The P100 latency on pVEP at the time of initial diagnosis was significantly related to the visual improvement after occlusion therapy or glasses in patients with strabismic, anisometropic, and isometropic amblyopia. Therefore, it was presumed that patients with a delayed P100 latency might have less visual improvement after occlusion therapy or glasses. In addition, there was no apparent difference in P100 latency between patients with strabismic and non-strabismic (anisometropic or isometropic) amblyopia.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Jong Bok(이종복)
Chung, Woo Suk(정우석)
Han, Seung Han(한승한) ORCID logo https://orcid.org/0000-0001-8972-4790
Hong, Sa Min(홍사민)
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